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Correspondence |

Elderly Individuals With FTLD

Atik Baborie, MD; Tim D. Griffiths, DM; Evelyn Jaros, PhD; Parastoo Momeni, PhD; Ian G. McKeith, MD; David J. Burn, MD; G. Keir, PhD; Andrew J. Larner, MD; David M. Mann, PhD; Robert Perry, MD
JAMA Neurol. 2013;70(3):412-413. doi:10.1001/jamaneurol.2013.1649.
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We thank Dr Jellinger for describing 2 additional cases of frontotemporal lobar degeneration (FTLD) in elderly individuals with tauopathy (FTLD-tau) with similar clinical signs and symptoms and neuropathological features to those we have described in our earlier study.1 Both female patients presented with cognitive symptoms, including memory loss, and showed hippocampal sclerosis. However, in patient 1, it is not mentioned whether TDP-43 changes were present. To what extent Braak stage IV could be compatible with all clinical changes mentioned is not certain, but it probably could account for the amnestic symptoms; however, whether these could also explain the frontal lobe signs is uncertain given that under Braak stage IV, tau pathology within frontal lobes would be sparse. We and others13 have found that when hippocampal sclerosis is present in FTLD, there is nearly always an accompanying TDP-43 (or FUS) pathology; hippocampal sclerosis is much less common in FTLD-tau.

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March 1, 2013
Kurt A. Jellinger, MD
JAMA Neurol. 2013;70(3):412-413. doi:10.1001/2013.jamaneurol.552.
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