0
We're unable to sign you in at this time. Please try again in a few minutes.
Retry
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
Retry
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Editorial |

Contribution of Cerebrovascular Health to the Diagnosis of Alzheimer Disease

Karen M. Rodrigue, PhD
JAMA Neurol. 2013;70(4):438-439. doi:10.1001/jamaneurol.2013.1862.
Text Size: A A A
Published online

Extract

Sporadic Alzheimer disease (AD) is a multifaceted neurodegenerative syndrome with complicated and unclear etiology that results in debilitating cognitive decline in old age. Although several decades of AD research resulted in major scientific advancements in identifying and tracking the disease, as well as discovering many salient genetic and environmental factors, considerably less progress in the development of efficacious therapies has been made. A major challenge for the field has been identifying sensitive and specific markers for detection in early stages of the disease, because by the time clinical symptoms are present, neuropathology is already quite advanced.1 Understanding the cascade of events that is unique to AD is complicated by the fact that AD exhibits a diverse clinical presentation and is often concomitant with other types of brain injury and dementia. A common example of this comorbidity is vascular disease, which can act as a risk factor for AD2 but also contributes to cognitive decline in its own right.3 Understanding the nature of the contributions of vascular pathology to AD is an important (and open) area of current research. Knowing if cerebrovascular disease plays an early and initiating role in the formation of AD neuropathology may have a significant impact on strategies to treat or even prevent the disease since vascular diseases are often highly responsive to treatment. However, cerebrovascular disease may simply occur in parallel to the development of AD pathology as a correlate and by-product of the aging process. Research examining the impact of various vascular health risk factors and specific neurovascular changes that can be measured in the human brain in vivo, along with biomarkers for AD (eg, β-amyloid [Aβ] positron emission tomography imaging of aggregated fibrillar amyloid plaque), are needed to elucidate this question.

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

First Page Preview

View Large
First page PDF preview

Figures

Tables

References

Correspondence

CME
Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
Submit a Comment

Multimedia

Some tools below are only available to our subscribers or users with an online account.

Web of Science® Times Cited: 1

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

Related Content

Customize your page view by dragging & repositioning the boxes below.

See Also...
Articles Related By Topic
Related Collections
PubMed Articles
Delusion of Pregnancy: An Unusual Symptom in the Context of Dementia. Am J Alzheimers Dis Other Demen Published online Sep 5, 2014.;
Jobs
JAMAevidence.com

Users' Guides to the Medical Literature
Clinical Resolution

Users' Guides to the Medical Literature
Clinical Scenario

brightcove.createExperiences();