Accepted for Publication: November 27, 2012.
Published Online: February 4, 2013. doi:10.1001/jamaneurol.2013.1933
Author Contributions:Study concept and design: Irwin, Schonberger, Lee, and Trojanowski. Acquisition of data: Irwin, Abrams, Schonberger, Leschek, Mills, Lee, and Trojanowski. Analysis and interpretation of data: Irwin, Abrams, Schonberger, Leschek, Mills, Lee, and Trojanowski. Drafting of the manuscript: Irwin, Abrams, Schonberger, and Trojanowski. Critical revision of the manuscript for important intellectual content: Irwin, Abrams, Schonberger, Leschek, Mills, Lee, and Trojanowski. Statistical analysis: Irwin, Abrams, and Schonberger. Obtained funding: Schonberger, Mills, Lee, and Trojanowski. Administrative, technical, and material support: Leschek. Study supervision: Trojanowski.
Conflict of Interest Disclosures: The authors report no financial disclosures related to the current study. Drs Lee and Trojanowski report single consulting services to Pfizer, Johnson & Johnson, MetLife, and Bristol-Myers Squibb; royalty payments through Penn licenses; and research support from AstraZeneca and Bristol-Myers Squibb.
Funding/Support: This study was supported by grant P30 AG010124-20, an AD Core Centre grant, and grant T32-AG000255 from the National Institute on Aging and Intramural Research Program and the National Institute of Child Health and Development, National Institutes of Health.
Disclaimer: The findings and conclusions in this report are those of the authors and do not necessarily represent the views of the Centers for Disease Control and Prevention.
Additional Contributions: We thank P. Brown, MD, and D. M. Asher, MD, for insightful comments and communication on previous National Institutes of Health primate studies and Kurt Brunden, PhD, Kelvin Luk, PhD, Adam Walker, PhD, and Jiali Li, PhD, and Jing Gou and Kaylan Tripathy for thoughtful critiques of the manuscript. We also thank Melanie Cedrone, Theresa Schuck, John Robinson, Kevin Raible, and Jonathan Bekisz for technical assistance.