Accepted for Publication: July 17, 2012.
Published Online: January 21, 2013. doi:10.1001/jamaneurol.2013.1960
Author Contributions:Study concept and design: Boster, Nicholas, Morgan-Followell, and Pitt. Acquisition of data: Boster, Topalli, Kisanuki, Pei, Morgan-Followell, Kirsch, and Pitt. Analysis and interpretation of data: Boster, Nicholas, Kirsch, Racke, and Pitt. Drafting of the manuscript: Boster, Nicholas, Topalli, Pei, Kirsch, and Pitt. Critical revision of the manuscript for important intellectual content: Boster, Nicholas, Topalli, Kisanuki, Morgan-Followell, Kirsch, Racke, and Pitt. Obtained funding: Pitt. Administrative, technical, and material support: Boster, Nicholas, Topalli, and Pei. Study supervision: Boster, Nicholas, Kirsch, Racke, and Pitt.
Conflict of Interest Disclosures: Dr Boster has received consulting fees from Biogen Idec, Genzyme, Teva Neuroscience, Novartis, Merck Serono, and Metronics. He has received research grants from Biogen Idec, Novartis, Actillion, Accorda, and Merck Serono. Dr Topalli is an employee of Biogen Idec. Dr Racke has received consulting fees from Biogen Idec, DioGenix, Elan, EMD Serono, Novartis, and Revalesio. Dr Pitt has received funding from FivePrime, Biogen Idec, Novartis, and Teva Pharmaceuticals for investigator-initiated trials. He also received consulting fees from Biogen Idec.
Funding/Support: This was supported in part by a Sylvia Lawry Physician Fellowship (Dr Nicholas) from the National Multiple Sclerosis Society. Dr Morgan-Followell was supported by a Clinical Care Physician Fellowship Award from the National Multiple Sclerosis Society.
Additional Contributions: We thank Eugene Major, PhD (National Institutes of Health), for helpful discussion and R. Chaudhury, MD (The Ohio State University), for help with the pathological specimen.