Accepted for Publication: March 9, 2012.
Published Online: October 8, 2012. doi:10.1001/jamaneurol.2013.579
Author Contributions: Drs Guerreiro and Lohmann contributed equally to this work. Drs Hardy, Guerreiro, and Lohmann had full access to all the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis. Study concept and design: Hanagasi, Emre, Singleton, and Hardy. Acquisition of data: Guerreiro, Lohmann, Gurunlian, Dursun, Bilgic, Hanagasi, Gurvit, and Singleton. Analysis and interpretation of data: Guerreiro, Brás, Gibbs, Rohrer, and Hardy. Drafting of the manuscript: Lohmann, Dursun, and Hardy. Critical revision of the manuscript for important intellectual content: Guerreiro, Lohmann, Brás, Gibbs, Rohrer, Gurunlian, Bilgic, Hanagasi, Gurvit, Emre, Singleton, and Hardy. Obtaining funding: Emre, Singleton, and Hardy. Administrative, technical, and material support: Guerreiro, Lohmann, Brás, Gibbs, Gurunlian, Dursun, Bilgic, and Hanagasi. Study supervision: Emre, Singleton, and Hardy.
Financial Disclosure: None reported.
Funding/Support: This work was supported in part by the Intramural Research Program of the National Institute on Aging, National Institutes of Health, Department of Health and Human Services, project Z01 AG000950-06, Alzheimer's Research UK, an Istanbul Neuropsychiatric Hospital (NPIstanbul) research grant, the Motor Neurone Disease Association, and an anonymous donor.
Additional Contributions: We thank all the patients and their families. Nihan Unaltuna-Erginel, PhD, helped with DNA management and Ali Bayram, BSc, provided technical help.