Accepted for Publication: August 30, 2012.
Published Online: December 24, 2012. doi:10.1001/jamaneurol.2013.668
Author Contributions:Study concept and design: Kieseier, Stüve, Ringelstein, and Aktas. Acquisition of data: Kieseier, Stüve, Dehmel, Goebels, Leussink, Mausberg, Ringelstein, Turowski, and Aktas. Analysis and interpretation of data: Kieseier, Stüve, Mausberg, Aktas, Antoch, and Hartung. Drafting of the manuscript: Kieseier, Stüve, Leussink, and Aktas. Critical revision of the manuscript for important intellectual content: Kieseier, Stüve, Dehmel, Goebels, Mausberg, Ringelstein, Turowski, Aktas, Antoch, and Hartung. Statistical analysis: Stüve. Obtained funding: Kieseier and Aktas. Administrative, technical, and material support: Kieseier, Stüve, Dehmel, Goebels, Leussink, Mausberg, Ringelstein, Aktas, and Antoch. Study supervision: Kieseier, Stüve, Turowski, Aktas, and Antoch.
Conflict of Interest Disclosures: None reported.
Funding/Support: This work was supported by grants from the German Ministry for Education and Research (Bundesminsterium für Bildung und Forschung [BMBF]), “German Competence Network Multiple Sclerosis” (Krankheitsbezogenes Kompetenznetz Multiple Sklerose), 01GI1002 (Dr Kieseier). The research leading to these results has received support from the Innovative Medicines Initiative Joint Undertaking under grant agreement 115303, resources of which are composed of financial contribution from the European Union's Seventh Framework Programme (Framework Programme 7/2007-2013) and European Federation of Pharmaceutical Industries and Associations companies' in kind contribution (Drs Kieseier and Hartung). The Multiple Sclerosis Center at the Department of Neurology, Heinrich-Heine-Universität Düsseldorf, is supported in part by the Walter-and Ilse-Rose Stiftung (Drs Aktas and Hartung), the Eugéne Devic European Network (E-rare/EU-FP7) (Drs Aktas and Hartung), and the German Ministry for Education and Research BMBF (01GM1203A) (Drs Aktas and Hartung).
Role of the Sponsor: The funders had no role in the design and conduct of the study; in the collection, analysis, and interpretation of the data; or in the preparation, review, or approval of the manuscript.