Accepted for Publication: October 17, 2012.
Published Online: December 10, 2012. doi:10.1001/jamaneurol.2013.1453
Author Contributions:Study concept and design: Walker, Diamond, Duff, and Hyman. Acquisition of data: Walker, Diamond, Duff, and Hyman. Analysis and interpretation of data: Walker, Diamond, Duff, and Hyman. Drafting of the manuscript: Walker, Diamond, Duff, and Hyman. Critical revision of the manuscript for important intellectual content: Walker, Diamond, Duff, and Hyman. Obtained funding: Walker, Diamond, Duff, and Hyman. Administrative, technical, and material support: Walker, Diamond, Duff, and Hyman. Study supervision: Walker, Diamond, Duff, and Hyman.
Conflict of Interest Disclosures: Dr Hyman has stock options with Novartis and consults or has sponsored research agreements for Pfizer, Neurophage, Neotope, Biogen, GlaxoSmithKline, Siemens, Elan, Accumen, and Takeda, none of which were involved in these projects.
Funding/Support: This work was supported by grants R21AG040589, P51RR165, P51OD11132, and P01AG005119 (Dr Walker), R01NS071835 (Dr Diamond), 1F31NS079039 and R01NS074874 (Dr Duff), and R21AG038835-01A1 and R21NS067127 (Dr Hyman) from the National Institutes of Health, by grants from the CART Foundation (Dr Walker), Muscular Dystrophy Association (Dr Diamond), Tau Consortium (Dr Diamond), and American Health Assistance Foundation (Drs Diamond and Hyman), and by a postdoctoral fellowship from the American Health Assistance Foundation (Dr Duff's laboratory).
Previous Presentation: This work was presented at the Alzheimer's Disease Centers Meeting; April 21, 2012; New Orleans, Louisiana.
Additional Contributions: We gratefully acknowledge the invaluable contributions of our collaborators and coworkers, in particular Mathias Jucker, PhD, Harry LeVine, PhD, Rebecca Rosen, PhD, Amarallys Cintron, BS, Li Liu, PhD, Jessica Wu, PhD, Alix de Calignon, MSc, Manuela Polydoro, PhD, Tara Spires, DPhil, George Carlson, PhD, Karen Ashe, PhD, and Mark Mayford, PhD. In addition, Dr Polydoro assisted with figure preparation and Brandon B. Holmes, BS, provided cell images and editorial comments to Dr Diamond.