0
We're unable to sign you in at this time. Please try again in a few minutes.
Retry
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
Retry
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
This Month in Archives of Neurology |

This Month in Archives of Neurology FREE

Arch Neurol. 2012;69(12):1543-1544. doi:10.1001/archneurol.2011.1489.
Text Size: A A A
Published online

DOPA-RESPONSIVE DYSTONIA REVISITED

Tadic and colleaguesArticle searched the MEDLINE database for patients with clinically typical dopa-responsive dystonia (DRD) and/or guanosine triphosphate cyclohydrolase I (GCH1) gene mutations from 1952 to 2011 and examined a pilot cohort of 23 outpatients with DRD and GCH1 mutations to investigate the delay in diagnosis, residual motor signs, and nonmotor signs of DRD.

SUBSTITUTION MONOTHERAPY WITH LEVETIRACETAM VS OLDER ANTIEPILEPTIC DRUGS: A RANDOMIZED COMPARATIVE TRIAL

Hakami et alArticle determine whether patients who fail their first antiepileptic drug (AED) have better neuropsychiatric and quality-of-life outcomes if substituted to levetiracetam monotherapy compared with a second older AED.

SHARED PREDISPOSITIONS OF PARKINSONISM AND CANCER: A POPULATION-BASED PEDIGREE-LINKED STUDY

Kareus and colleaguesArticle used a computerized genealogy for the Utah pioneers and their descendants linked to a statewide cancer registry and statewide death certificates to estimate relative risks for cancer in individuals with Parkinson disease listed on their death certificate and among their first-degree, second-degree, and third-degree relatives. Editorial perspective is provided by Walter A. Rocca, MD, MPHArticle.

DIFFERENTIAL DIAGNOSIS OF JAKOB-CREUTZFELDT DISEASE

In a retrospective medical record review, Paterson et alArticle identify the misdiagnoses of patients with sporadic Jakob-Creutzfeldt disease during the course of their disease and determine which medical specialties saw patients with sporadic Jakob-Creutzfeldt disease prior to the correct diagnosis being made and at what point in the disease course a correct diagnosis was made. Editorial perspective is provided by Richard J. Caselli, MDArticle.

INVESTIGATION OF C9ORF72 IN 4 NEURODEGENERATIVE DISORDERS

Using a 2-step genotyping strategy, Xi et alArticle estimate the allele frequency of C9orf72 (G4C2) repeats in amyotrophic lateral sclerosis, frontotemporal lobar degeneration, Alzheimer disease, and Parkinson disease.

Β-AMYLOID DYNAMICS IN HUMAN PLASMA

In a repeated plasma and cerebrospinal fluid sampling study, Huang et alArticle investigate dynamic changes in human plasma β-amyloid concentrations, evaluate the effects of aging and amyloidosis on these dynamics, and determine their correlation with cerebrospinal fluid β-amyloid concentrations.

ADULT-ONSET OPSOCLONUS-MYOCLONUS SYNDROME

Klaas et alArticle evaluate 21 adults with opsoclonus-myoclonus syndrome (OMS) and review the literature to contribute to the sparse data available on adult-onset OMS. Paraneoplastic and parainfectious causes (particularly human immunodeficiency virus) should be considered. Complete remission achieved with immunotherapy is the most common outcome.

“UNEQUIVOCALLY ABNORMAL” VS “USUAL” SIGNS AND SYMPTOMS FOR PROFICIENT DIAGNOSIS OF DIABETIC POLYNEUROPATHY

After a previous trial resulted in inaccurate assessment of diabetic sensorimotor polyneuropathy, Dyck et alArticle used more specific diagnostic criteria and compared findings with nerve conduction studies.

STROKE FROM ACUTE CERVICAL INTERNAL CAROTID ARTERY OCCLUSION: TREATMENT RESULTS AND PREDICTORS OF OUTCOME

To describe the outcomes of intravenous thrombolysis or endovascular treatment in patients with stroke from acute cervical internal carotid artery occlusion, Seet and colleaguesArticle performed among 21 patients a retrospective study of the associations of vascular predictor variables with favorable functional recovery at 90 days after stroke.

REGIONAL WHITE MATTER HYPERINTENSITY VOLUME, NOT HIPPOCAMPAL ATROPHY, PREDICTS INCIDENT ALZHEIMER DISEASE IN THE COMMUNITY

In a longitudinal community-based epidemiological study of older adults from northern Manhattan, New York, Brickman et alArticle determine whether regional white matter hyperintensities and hippocampal volume predict incident Alzheimer disease.

Place holder to copy figure label and caption

Graphic Jump LocationImage not available.

For illustration, cumulative survival curves were generated that compared individuals with high white matter hyperintensity volumes in the parietal lobes, defined here as the top quartile (dotted line), with all other participants, defined as the bottom 3 quartiles (solid line). MRI indicates magnetic resonance imaging.

CEREBRAL AMYLOID DEPOSITION AND SEROTONINERGIC INNERVATION IN PARKINSON DISEASE

Kotagal and colleaguesArticle determine whether serotoninergic system degeneration in Parkinson disease (PD) promotes β-amyloid deposition, using in vivo positron emission tomographic probes of serotonin system integrity and β-amyloid deposition.

IMPACT OF ANGIOTENSIN RECEPTOR BLOCKERS ON ALZHEIMER DISEASE NEUROPATHOLOGY IN A LARGE BRAIN AUTOPSY SERIES

Hajjar and colleaguesArticle evaluate the impact of treatment with angiotensin receptor blockers (ARBs) on the neuropathology of Alzheimer disease (AD) in the National Alzheimer Coordinating Center database, which includes aggregated data and brain autopsies from 29 AD centers throughout the United States. Treatment with ARBs is associated with less AD-related pathology on autopsy evaluations.

First Page Preview

View Large
First page PDF preview

Figures

Place holder to copy figure label and caption

Graphic Jump LocationImage not available.

For illustration, cumulative survival curves were generated that compared individuals with high white matter hyperintensity volumes in the parietal lobes, defined here as the top quartile (dotted line), with all other participants, defined as the bottom 3 quartiles (solid line). MRI indicates magnetic resonance imaging.

Tables

References

Correspondence

CME
Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
Submit a Comment

Multimedia

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging & repositioning the boxes below.