Accepted for Publication: August 8, 2012.
Published Online: December 3, 2012. doi:10.1001/2013.jamaneurol.286
Author Contributions:Study concept and design: Chen, Langbaum, Fleisher, Caselli, and Reiman. Acquisition of data: Bandy, Mosconi, Buckley, Schuff, Weiner, Caselli, and Reiman. Analysis and interpretation of data: Protas, Chen, Fleisher, Alexander, Lee, de Leon, Truran-Sacrey, Caselli, and Reiman. Drafting of the manuscript: Protas, Chen, Fleisher, and Reiman. Critical revision of the manuscript for important intellectual content: Protas, Chen, Langbaum, Fleisher, Alexander, Lee, Bandy, de Leon, Mosconi, Buckley, Truran-Sacrey, Schuff, Weiner, Caselli, and Reiman. Statistical analysis: Protas, Chen, Alexander, Schuff, and Reiman. Obtained funding: Weiner and Reiman. Administrative, technical, and material support: Bandy, Mosconi, Buckley, Truran-Sacrey, Weiner, Caselli, and Reiman. Study supervision: Fleisher, Truran-Sacrey, Schuff, Weiner, and Reiman.
Conflict of Interest Disclosures: Dr Mosconi has a patent on a technology that was licensed to Abiant Inc by New York University and, as such, has a financial interest in this license agreement and holds stock and stock options in the company. Dr Mosconi has also received compensation for consulting services from Abiant Inc. Dr Weiner reported that he was on the scientific advisory boards of Lilly, Araclon, Institut Catala de Neurociencies Aplicades, Gulf War Veterans Advisory Committee, and Biogen Idec in 2010 and Pfizer in 2011; that he consulted for AstraZeneca, Araclon, Medivation/Pfizer, Ipsen, TauRx Therapeutics, Bayer HealthCare, Biogen Idec, ExonHit Therapeutics, Servier, and Synarc in 2010 and Pfizer and Janssen in 2011; that he received funding for travel from NeuroVigil, CHRU Hôpital Roger Salengro, Siemens, AstraZeneca, Geneva University Hospitals, Lilly, University of California, San Diego–Alzheimer's Disease Neuroimaging Initiative (ADNI), Paris University, Institut Catala de Neurociencies Aplicades, University of New Mexico School of Medicine, Ipsen, and Clinical Trials on Alzhimer's Disease in 2010 and Pfizer, The Alzheimer's & Parkinson's Conference, Paul Sabatier University, Novartis, and Tohoku University in 2011; that he was on the editorial advisory board of Alzheimer's Disease & Dementia and Magnetic Resonance Imaging; that he received honoraria from NeuroVigil and Institut Catala de Neurociencies Aplicades in 2010 and Pharmaceuticals and Medical Devices Agency/Japanese Ministry of Health, Labour, and Welfare and Tohoku University in 2011; that he received commercial entities research support from Merck and Avid; that he received government entities research support from the US Department of Defense and the Department of Veterans Affairs; and that he has stock options in Synarc and Elan. The organizations contributing to the foundation for the National Institutes of Health, and thus to the National Institute on Aging–funded ADNI, are Abbott, the Alzheimer's Association, the Alzheimer's Drug Discovery Foundation, the Anonymous Foundation, AstraZeneca, Bayer HealthCare, BioClinica (ADNI 2), Bristol-Myers Squibb, the Cure Alzheimer's Fund, Eisai, Elan, Gene Network Sciences, Genentech, GE Healthcare, GlaxoSmithKline, Innogenetics, Johnson & Johnson, Lilly, Medpace, Merck, Novartis, Pfizer, Roche, Schering Plough, Synarc, and Wyeth.
Funding/Support: This work was supported by the National Institute of Mental Health (grant R01MH57899 to Dr Reiman), the National Institute on Aging (grants R01AG031581 and P30AG19610 to Dr Reiman and grant R01AG025526 to Dr Alexander), the state of Arizona (to Drs Chen, Alexander, Caselli, and Reiman), and contributions from the Banner Alzheimer's Foundation and the Mayo Clinic Foundation.
Online-Only Material: Listen to an author interview about this article, and others, at http://bit.ly/MT7xg4.
Additional Contributions: We thank Patti Aguilar, Christine Burns, MA, Sandra Goodwin, Bruce Henslin, BBA, Candy Monarrez, Anita Prouty, BS, Cole Reschke, BS, Nicole Richter, BS, and Sandra Yee-Benedetto, MHA, for their assistance.