Accepted for Publication: July 13, 2012.
Published Online: November 19, 2012. doi:10.1001/jamaneurol.2013.599
Author Contributions:Study concept and design: Scalfari, Daumer, Muraro, and Ebers. Acquisition of data: Scalfari, Daumer, and Ebers. Analysis and interpretation of data: Scalfari, Neuhaus, Daumer, DeLuca, and Ebers. Drafting of the manuscript: Scalfari and Ebers. Critical revision of the manuscript for important intellectual content: Scalfari, Neuhaus, Daumer, DeLuca, Muraro, and Ebers. Statistical analysis: Scalfari, Neuhaus, and Daumer. Obtained funding: Scalfari, Daumer, Muraro, and Ebers. Administrative, technical, and material support: Scalfari, Daumer, DeLuca, and Ebers. Study supervision: Scalfari, Daumer, Muraro, and Ebers.
Conflict of Interest Disclosures: Dr Scalfari has received research support from the Italian Multiple Sclerosis Foundation (FISM). Ms Neuhaus receives research support from the German Ministry for Education and Research (BMBF). Dr Daumer serves on the scientific advisory board for European Project on Osteoarthritis Study; has received funding for travel from the European Committee for Treatment and Research in Multiple Sclerosis; serves on the editorial board of MedNous; and is a patent holder for an apparatus for measuring activity (Trium Analysis Online GmbH), a method and device for detecting a movement pattern (Trium Analysis Online GmbH), a device and method to measure the activity of a person, a device and method to determine the fetal heart rate from ultrasound signals, a method and device for detecting drifts, jumps, and/or outliers of measurement values, a device and method to determine the global alarm state of a patient monitoring system, a method of communication of units in a patient-monitoring system, and a system and method for patient monitoring; serves as managing director of and holds stock/stock options in Trium Analysis Online GmbH (50% effort); serves as a consultant for University of Oxford, Imperial College London, University of Southampton, Charite, Berlin, University of Vienna, Greencoat Ltd, Biopartners, Biogen Idec, Bayer Schering Pharma, Roche, and Novartis; and receives or has received research support from the European Union Seventh Framework Programme, BMBF, Budeswirtschaftsministerium (Germany Ministry for Economic Affairs), and Hertie Foundation. Dr DeLuca has received honoraria and travel expenses as an invited speaker for Bayer Schering and Teva Pharmaceutical Industries and is supported by the American Academy of Neurology Foundation/Consortium of Multiple Sclerosis Centers John F. Kurtzke Clinician-Scientist award, a Goodger Scholarship (University of Oxford), and the National Institute for Health Research Biomedical Research Centre, Oxford. Dr Muraro receives or has received research support from the Medical Research Council UK, UK Multiple Sclerosis Society/UK Stem Cell Foundation, and FISM and has received travel support or speaker honoraria from Sanofi Aventis, Biogen Idec, and Bayer. Dr Ebers serves on the editorial boards of the International Multiple Sclerosis Journal and Multiple Sclerosis and as section editor for BMC Medical Genetics; has received funding for travel or speaker honoraria from Bayer Schering Pharma, Sanofi-Aventis, Roche, and UCB; has served as a consultant to Biopartners, Bayer Schering Pharma, Howrey LLP, Heron Health, and Eli Lilly and Company; and receives research support from Bayer Schering Pharma, the Multiple Sclerosis Society of the United Kingdom, and the Multiple Sclerosis Society of Canada Scientific Research Foundation.
Funding/Support: This study was supported by the FISM (grant 2008/R/16), by grant G0800679 from the Medical Research Council, and by the MS Society of Canada and the UK MS Society. The work of the Sylvia Lawry Centre for Multiple Sclerosis Research was partly supported by grants 01GI0904 and 01GI0920 from BMBF/German Competence Network.