Accepted for Publication: July 9, 2012.
Published Online: November 5, 2012. doi:10.1001/jamaneurol.2013.598
Author Contributions:Study concept and design: Rudick, Polman, Clifford, Miller, and Steinman. Acquisition of data: Clifford, Miller, and Steinman. Analysis and interpretation of data: Clifford, Miller, and Steinman. Drafting of the manuscript: Rudick, Polman, Clifford, Miller, and Steinman. Critical revision of the manuscript for important intellectual content: Rudick, Polman, Clifford, Miller, and Steinman. Statistical analysis: Steinman. Obtained funding: Steinman. Administrative, technical, and material support: Polman, Clifford, and Steinman. Study supervision: Rudick, Clifford, and Steinman.
Conflict of Interest Disclosures: Dr Rudick has received payment as a consultant for Biogen Idec, Genzyme, and Novartis, as well as grants from Biogen Idec. Dr Polman and his institution have received compensation for his consultancy, development of educational materials, participation on speakers bureaus, and travel expenses from Actelion, Bayer Schering, Biogen Idec, GlaxoSmithKline, Merck Serono, MorphoSys, Novartis, Roche, Teva, and UCB. He has also been compensated by Biogen Idec for giving expert testimony; his institution has received grants from Bayer Schering, Biogen Idec, GlaxoSmithKline, Merck Serono, Novartis, Teva, and UCB. Dr Clifford has received payment as a consultant from Biogen Idec, Bristol Myers-Squibb, Genentech, Genzyme, Jannsen, Millennium, and Pfizer. He has also been compensated by Biogen Idec for giving expert testimony; he has received compensation for being on speakers bureaus from Biogen Idec, GlaxoSmithKline, and Millennium, as well as for developing educational materials from Genentech and Millennium. He has received payment from Millennium as a member of an independent adjudication committee, from Genzyme as chair of the data monitoring committee, from Genentech for being on a panel of experts, and from Pfizer for being a member of data safety monitoring boards. Dr Miller's institution has been compensated by Biogen Idec for his providing services or equipment/medicines; by Bayer Schering, Biogen Idec, Merck Serono, and Novartis for his board membership; and by Biogen Idec and Novartis for his speaker bureau activities. His institution has also received grants from Biogen Idec, GlaxoSmithKline, and Novartis, as well as payment for Dr Miller's consultancy. Dr Steinman has received honoraria for patents and stock options from Elan; he has received compensation from Biogen Idec as a consultant.
Funding/Support: Biogen Idec provided funding for editorial support for the development of this article.
Role of the Sponsor: Biogen Idec reviewed the manuscript and provided feedback. The authors had full editorial control of the manuscript and provided their final approval of all content.
Additional Contributions: Medical writing assistance was provided by Katherine Hauswirth, MSN, and editorial support was provided by Jackie Cannon, BS, both of Infusion Communications. Their work was funded by Biogen Idec Inc.