Editorial | ONLINE FIRST

Getting Beyond the Ganglion Cell:  Morphometric Adjustments for Retinal Optical Coherence Tomography in Multiple Sclerosis ONLINE FIRST

Ari J. Green, MD, MCR
Arch Neurol. Published online October 01, 2012. doi:10.1001/archneurol.2013.430
Text Size: A A A
Published online


The treatment of relapsing multiple sclerosis (MS) remains a rare beacon of success in the long campaign against neurological disease. The ready availability of a phase II clinical outcome (eg, gadolinium-enhancing lesion) that tracks a relevant phase III clinical outcome (eg, annualized relapse rate) is one of the major reasons for this success. Eight therapies have been approved by the US Food and Drug Administration in less than 20 years, and 3 more are under current consideration at the Food and Drug Administration following successful phase III clinical programs. However, before feeling triumphant, we must recognize that our current therapies are principally effective in the prevention of relapses and new brain lesions detected using magnetic resonance imaging (MRI) and that their therapeutic benefit over the long term remains a matter of controversy.1,2 In fact, it is widely agreed that we lack robust, potent therapies to overcome the fearsome long-term progressive neurological decline that characterizes MS. Furthermore, this progressive neurological decline manifests itself in the later stages of the disease and appears irreversible once it appears—facts that make it difficult to adequately time therapeutic intervention and assess its effects. As a result, progressive MS is an arena in desperate need of compelling biomarkers and predictors of disease course. Precisely for this reason, retinal optical coherence tomography (OCT) has garnered great interest as a potential phase II clinical outcome in neuroprotective trials in MS. Nearly 200 papers have been published on the topic in the last 8 years (as of July 2012 in MEDLINE).

Sign In to Access Full Content

Don't have Access?

Register and get free email Table of Contents alerts, saved searches, PowerPoint downloads, CME quizzes, and more

Subscribe for full-text access to content from 1998 forward and a host of useful features

Activate your current subscription (AMA members and current subscribers)

Purchase Online Access to this article for 24 hours

First Page Preview

View Large
First page PDF preview





Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).
Submit a Comment


Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

Related Content

Customize your page view by dragging & repositioning the boxes below.

Articles Related By Topic
Related Topics