Accepted for Publication:: March 16, 2012.
Published Online: September 10, 2012. doi:10.1001/archneurol.2012.764
Author Contributions: Dr Kotagal had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis. Study concept and design: Kotagal, Frey, and Albin. Acquisition of data: Kotagal, Bohnen, Müller, and Koeppe. Analysis and interpretation of data: Kotagal, Bohnen, Müller, Koeppe, Frey, and Albin. Drafting of the manuscript: Kotagal and Albin. Critical revision of the manuscript for important intellectual content: Kotagal, Bohnen, Müller, Koeppe, Frey, and Albin. Statistical analysis: Kotagal, Bohnen, Müller, and Koeppe. Obtained funding: Bohnen, Frey, and Albin. Administrative, technical, and material support: Koeppe. Study supervision: Bohnen, Müller, and Albin.
Financial Disclosure: Dr Kotagal receives funding from the Clinical Research Training Fellowship of the American Academy of Neurology. Dr Bohnen has received grant funding from the National Institutes of Health. Dr Frey has been a consultant for Avid Radiopharmaceuticals, Bayer Schering Pharma, and MIMvista, has received grants from General Electric, and has stock or stock options in General Electric. Dr Albin has received compensation for acting as an expert witness in litigation concerning dopamine agonist–induced impulse control disorders, receives research funding from the National Institutes of Health and the Department of Veterans Affairs, is on the editorial boards of Neurology, Neurobiology of Disease, and Experimental Neurology, and serves on the Data Monitoring and Safety Committee for the QE3 trial.
Funding/Support: This work was supported by the Michael J. Fox Foundation, the Department of Veterans Affairs, grants P01 NS015655 and R01 NS070856 from the National Institutes of Health, and a gift from an anonymous donor.
Additional Contributions: Christine Minderovic, BA, assisted in human subject study coordination, Virginia Rogers, BA, assisted in PET imaging study coordination, and PET technologists, cyclotron operators, and chemists provided assistance.