Accepted for Publication: June 7, 2012.
Published Online: September 3, 2012. doi:10.1001/archneurol.2012.2203
Author Contributions: Drs Hakami and Todaro contributed equally to the literature review. Study concept and design: MacGregor, Yerra, and O’Brien. Acquisition of data: Hakami, Todaro, Petrovski, Tan, Matkovic, Yerra, and O’Brien. Analysis and interpretation of data: Hakami, Todaro, Petrovski, MacGregor, Velakoulis, Gorelik, Liew, Yerra, and O’Brien. Drafting of the manuscript: Hakami, Todaro, Gorelik, Liew, Yerra, and O’Brien. Critical revision of the manuscript for important intellectual content: Hakami, Todaro, Petrovski, MacGregor, Velakoulis, Tan, Matkovic, Liew, Yerra, and O’Brien. Statistical analysis: Hakami, Todaro, Petrovski, MacGregor, and Liew. Obtained funding: Yerra and O’Brien. Administrative, technical, and material support: Todaro, Tan, Yerra, and O’Brien. Study supervision: Todaro, Matkovic, Gorelik, Liew, and O’Brien.
Financial Disclosure: Dr MacGregor has received research support from CSL, Amrad, Biogen Idec, and Prana and is currently an employee of Roche. Dr O’Brien has received research support from UCB Pharma, Sanofi, Janssen-Cilag, and Novartis as well as competitive grant support from the National Health and Medical Research Council and the Royal Melbourne Hospital Research Foundation.
Funding/Support: This was an investigator-initiated study partly funded by UCB Pharma as well as the Royal Melbourne Hospital Neuroscience Foundation. Dr Hakami was supported by a PhD scholarship from Jazan University, Jazan, Saudi Arabia.
Role of the Sponsor: UCB Pharma played no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; or preparation, review, or approval of the manuscript.
Additional Contributions: Chris French, MB, BS, PhD, Department of Neurology, Royal Melbourne Hospital, assisted with patient recruitment and Annie Roten, BBioSci, and Tess Bright, BSc, Department of Neurology, Royal Melbourne Hospital, assisted with data collection.