Accepted for Publication: April 30, 2012.
Published Online: August 27, 2012. doi:10.1001/archneurol.2012.1654
Author Contributions: Drs Hall, Öhrfelt, and Hansson had full access to all the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis. All authors reviewed, commented on, and approved the final report. Drs Hall and Öhrfelt contributed equally to the present work. Study concept and design: Widner, Blennow, and Hansson. Acquisition of data: Hall, Öhrfelt, Constantinescu, Surova, Bostrom, Nilsson, Widner, Decraemer, Nägga, Minthon, Londos, Vanmechelen, Holmberg, Blennow, and Hansson. Analysis and interpretation of data: Öhrfelt, Andreasson, Nilsson, Widner, Decraemer, Vanmechelen, Zetterberg, Blennow, and Hansson. Drafting of the manuscript: Hall, Öhrfelt, Widner, Minthon, Londos, Holmberg, and Hansson. Critical revision of the manuscript for important intellectual content: Hall, Öhrfelt, Constantinescu, Andreasson, Surova, Bostrom, Nilsson, Widner, Decraemer, Nägga, Minthon, Vanmechelen, Zetterberg, and Blennow. Statistical analysis: Hall, Öhrfelt, Andreasson, and Hansson. Obtained funding: Widner, Vanmechelen, Blennow, and Hansson. Administrative, technical, and material support: Hall, Constantinescu, Bostrom, Nilsson, Widner, Decraemer, Nägga, Minthon, Londos, Vanmechelen, Zetterberg, Blennow, and Hansson. Study supervision: Widner, Vanmechelen, Holmberg, Zetterberg, Blennow, and Hansson.
Conflict of Interest Disclosures: None reported.
Funding/Support: This study was supported by the Swedish Research Council, Swedish Alzheimer Foundation, Torsten and Ragnar Soderberg Foundation, Swedish Brain Power consortium, and the Regional Agreement on Medical Training and Clinical Research (ALF) between the Skåne County Council and Lund University and the Sahlgrenska University Hospital and the Sahlgrenska Academy.
Additional Contributions: We thank the patients and individuals who served as controls who contributed to the research. Without the dedication of all personnel at the Neurology and Memory clinics, this study would not have been possible.