Accepted for Publication: November 25, 2011.
Published Online: April 23, 2012. doi:10.1001/archneurol.2011.3323
Author Contributions:Study concept and design: Baborie, McKeith, Mann, and Perry. Acquisition of data: Baborie, Jaros, Momeni, McKeith, Burn, and Perry. Analysis and interpretation of data: Baborie, Griffiths, Jaros, Momeni, McKeith, Keir, Larner, Mann, and Perry. Drafting of the manuscript: Baborie, Griffiths, Momeni, Mann, and Perry. Critical revision of the manuscript for important intellectual content: Baborie, Griffiths, Jaros, McKeith, Burn, Keir, Larner, Mann, and Perry. Statistical analysis: Keir and Perry. Obtained funding: McKeith and Perry. Administrative, technical, and material support: Baborie, Griffiths, Momeni, Larner, Mann, and Perry. Study supervision: Baborie, Jaros, and Perry.
Financial Disclosure: None reported.
Funding/Support: Dr Jaros, Andrew Brown, senior BMS, and Lynne Ramsay, senior BMS, have been in part supported by the UK National Institute for Health Research Biomedical Research Centre for Ageing and Age-Related Disease Award to the Newcastle upon Tyne Hospitals NHS Foundation Trust. The Newcastle Brain Tissue Resource is funded in part by grants G0400074 and G1100540 from the UK Medical Research Council, the Newcastle NIHR Biomedical Research Centre in Ageing and Age Related Diseases award to the Newcastle upon Tyne Hospitals NHS Foundation Trust, and a grant from the Alzheimer’s Society and Alzheimer’s Research Trust as part of the Brains for Dementia Research Project.
Additional Contributions: We gratefully acknowledge the Newcastle Brain Tissue Resource, which manages all the brain tissue from the patients with FTLD used in this study. We thank all staff at the Neuropathology Department, Newcastle General Hospital, for technical assistance: Andrew Brown and Janet Thompson, senior BMS, for cutting and staining of the sections and Lynne Ramsay for the TDP-43 staining. We thank our patients, their relatives, and our colleagues for the diagnostic referrals.