Accepted for Publication: April 4, 2012.
Published Online: August 20, 2012. doi:10.1001/archneurol.2012.1122
Author Contributions:Study concept and design: Talbot and Turner. Acquisition of data: Knight and Turner. Analysis and interpretation of data: Menke, Abraham, Thiel, Filippini, and Turner. Drafting of the manuscript: Menke, Abraham, and Turner. Critical revision of the manuscript for important intellectual content: Thiel, Filippini, Knight, Talbot, and Turner. Statistical analysis: Menke, Abraham, Filippini, and Turner. Obtained funding: Turner. Administrative, technical, and material support: Talbot and Turner. Study supervision: Menke, Talbot, and Turner.
Conflict of Interest Disclosures: Dr Menke's work is funded by the Parkinson's Disease Society of the United Kingdom. Dr Turner's work is funded by Lady Edith Wolfson Fellowship grant G0701923 from the Medical Research Council/Motor Neurone Disease Association UK.
Funding/Support: The Oxford Motor Neuron Disease Care & Research Centre receives funding from the Motor Neurone Disease Association UK Care Centre Program.
Additional Contributions: We are indebted to Research Assistant Melanie Lord, BSc; Center Coordinator/Specialist Nurse Rachael Marsden, MSc; and our patients with amyotrophic lateral sclerosis and their caregivers.