Accepted for Publication: April 16, 2012.
Published Online: July 2, 2012. doi:10.1001/archneurol.2012.1300
Author Contributions:Study concept and design: Arellano, Hussain, Zein, Steinman, Greenberg, Lambracht-Washington, Bennett, and Stüve. Acquisition of data: Arellano, Zacharias, Yoon, David, Zein, Ritchie, Bennett, and Stüve. Analysis and interpretation of data: Arellano, Zacharias, Steinman, Forsthuber, Lambracht-Washington, Ritchie, Bennett, and Stüve. Drafting of the manuscript: Arellano, Yoon, Zein, Ritchie, Bennett, and Stüve. Critical revision of the manuscript for important intellectual content: Hussain, Zacharias, David, Steinman, Forsthuber, Greenberg, Lambracht-Washington, and Stüve. Statistical analysis: Arellano, Zacharias, Lambracht-Washington, Ritchie, Bennett, and Stüve. Obtained funding: Steinman, Greenberg, and Stüve. Administrative, technical, and material support: Hussain, Yoon, David, Zein, Steinman, Forsthuber, Greenberg, Lambracht-Washington, and Stüve. Study supervision: Zein, Steinman, and Stüve.
Financial Disclosure: None reported.
Funding/Support: Dr Stüve is a recipient of a Doris Duke Clinical Scientist Development Award. Work related to this study was supported by grant 2009036 from the Doris Duke Charitable Foundation. Dr Bennett is supported by research grant RG4320 from the Guthy-Jackson Charitable Foundation and the National Multiple Sclerosis Society.
Additional Contributions: The Guthy-Jackson Charitable Foundation made whole-length hAQP4 available to our laboratory. We also thank Linda S. Hynan, PhD, in the Department of Biostatistics at the University of Texas Southwestern Medical Center at Dallas for her support.