Accepted for Publication: April 9, 2012.
Published Online: June 4, 2012. doi:10.1001/archneurol.2012.1219
Author Contributions:Study concept and design: Ishiura, Takahashi, Kuzuhara, Ranum, Goto and Tsuji. Acquisition of data: Ishiura, Takahashi, Yoshida, Kihira, Kokubo, Kuzuhara, Tamaoki, Date, Goto, and Tsuji. Analysis and interpretation of data: Ishiura, Takahashi, Mitsui, Ichikawa, and Goto. Drafting of the manuscript: Ishiura, Yoshida, Kihira, Tamaoki, and Tsuji. Critical revision of the manuscript for important intellectual content: Takahashi, Mitsui, Kokubo, Kuzuhara, Ranum, Ichikawa, Date, Goto, and Tsuji. Statistical analysis: Ishiura and Tsuji. Obtained funding: Tsuji. Administrative, technical, and material support: Yoshida, Kihira, Kokubo, Kuzuhara, Ranum, Tamaoki, Ichikawa, Date, Goto, and Tsuji. Study supervision: Takahashi, Kuzuhara, Goto, and Tsuji.
Financial Disclosure: None reported.
Funding/Support: This work was supported in part by Grants-in-Aid for Scientific Research on Innovative Areas 22129001 and 22129002 from KAKENHI; funding from the Global COE Program from the Ministry of Education, Culture, Sports, Science, and Technology of Japan; Grant-in-Aid H23-Jitsuyoka (Nanbyo)-Ippan-004 to Dr Tsuji; funding from the Research Committee of CNS Degenerative Diseases; and grant 21210301 from the Research Committee of Muro disease (Kii ALS/PD) from the Ministry of Health, Welfare, and Labour, Japan, to Dr Kokubo. Dr Ishiura's work was supported by a research fellowship of the Japanese Society for the Promotion of Science for Young Scientists.
Additional Contributions: We deeply thank all the patients for participating in the study.