Accepted for Publication: October 11, 2011.
Published Online: February 20, 2012. doi:10.1001/archneurol.2011.2504
Author Contributions: *Drs Sequeiros and Nicholson contributed equally to this work. Drs Martins and Sequeiros had full access to all the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis. Study concept and design: Martins and Sequeiros. Acquisition of data: Martins, Soong, Wong, Giunti, Stevanin, Ranum, Sasaki, Riess, Tsuji, Coutinho, Amorim, Sequeiros and Nicholson. Analysis and interpretation of data: Martins, Amorim, and Sequeiros. Drafting of the manuscript: Martins. Critical revision of the manuscript for important intellectual content: Soong, Wong, Giunti, Stevanin, Ranum, Sasaki, Riess, Tsuji, Coutinho, Amorim, Sequeiros, and Nicholson. Obtained funding: Amorim and Sequeiros. Administrative, technical, and material support: Sequeiros and Nicholson. Study supervision: Amorim and Sequeiros.
Financial Disclosure: None reported.
Funding/Support: Dr Martins is the recipient of a scholarship (SFRH/BPD/29225/2006) from the Foundation for Science and Technology (FCT); IBMC and IPATIMUP are Associate Laboratories of the Ministry of Education and Science, partially supported by FCT. This work was co-financed by the European Social Fund (Human Potential Thematic Operational Programme).
Additional Contributions: The authors thank the traditional owners of eastern Arnhem Land and Groote Eylandt, their community representatives (in the person of Tony Wurramarrba, chairman of the Anindilyakwa Land Council), and, in particular, the affected families from Angurugu and Yirrkala. We are also thankful to the MJD Foundation (Australia), in particular to Libby Massey (director of Research and Community Services), Gayangwa Lalara (vice-chairperson and senior cultural advisor), and Nadia Lindop (executive officer), who were instrumental in our contacts with the communities, and for funding travel and lodging in Groote Eylandt. We are indebted to the Menzies School of Health Research, Darwin, New Territories, which provided the ethical review process from its Human Research Ethics Committee. We thank Nicholas Wood, PhD (University of London), and Alexis Brice, MD (Hôpital Pitié-Salpêtrière, Paris), for providing some DNA samples.