Accepted for Publication: March 6, 2012.
Published Online: May 7, 2012. doi:10.1001/archneurol.2012.595
Author Contributions: Drs Orange and Frank contributed equally to this article. Study concept and design: Darnell. Acquisition of data: Dousmanis, Marmur, Buckley, Parveen, and Graber. Analysis and interpretation of data: Orange, Frank, Tian, Dousmanis, Marmur, Graber, Blachère, and Darnell. Drafting of the manuscript: Orange, Frank, Tian, and Darnell. Critical revision of the manuscript for important intellectual content: Tian, Dousmanis, Marmur, Buckley, Parveen, Graber, Blachère, and Darnell. Statistical analysis: Frank and Tian. Obtained funding: Darnell. Administrative, technical, and material support: Orange, Frank, Marmur, Parveen, Graber, and Blachère. Study supervision: Darnell.
Financial Disclosure: None reported.
Funding/Support: This study was supported by grant R01 CA093507 from the National Institutes of Health, the American College of Rheumatology Research and Education Foundation Physician Scientist Development Award, and grants UL1RR024143 and 8 KL2 TR000151 from the National Institutes of Health's National Center for Research Resources and National Center for Advancing Sciences to The Rockefeller University Hospital. Dr Orange is the Beth and Ravenel Curry clinical scholar, and Dr Darnell is a Howard Hughes Medical Institute investigator.
Additional Contributions: We are grateful to the patients with paraneoplastic neurologic disorders who participated in this study and their families as well as the entire staff of The Rockefeller University Hospital for facilitating patient studies. We thank Jerome Posner, MD, for helpful discussions and for referring many of the patients in this study. We also thank members of our laboratories for helpful discussions and review of the article.