Accepted for Publication: September 30, 2011.
Published Online: March 12, 2012. doi:10.1001/archneurol.2011.3405
Author Contributions: All authors had full access to all of the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis. Study concept and design: Jack, Vemuri, Weigand, and Trojanowski. Acquisition of data: Jack, Lowe, Kantarci, Bernstein, Trojanowski, Shaw, Weiner, and Knopman. Analysis and interpretation of data: Jack, Vemuri, Wiste, Weigand, Lesnick, Lowe, Kantarci, Senjem, Gunter, Boeve, Trojanowski, Aisen, Weiner, Petersen, and Knopman. Drafting of the manuscript: Jack and Trojanowski. Critical revision of the manuscript for important intellectual content: Jack, Vemuri, Wiste, Weigand, Lesnick, Lowe, Kantarci, Bernstein, Gunter, Boeve, Trojanowski, Shaw, Aisen, Weiner, Petersen, and Knopman. Statistical analysis: J ack, Vemuri, Wiste, Weigand, Lesnick, Senjem, and Trojanowski. Obtained funding: Jack, Lowe, and Weiner. Administrative, technical, and material support: Jack, Kantarci, Bernstein, Senjem, Gunter, Boeve, and Weiner. Study supervision: Jack, Lowe, and Weiner.
Financial Disclosure: Dr Lowe receives grant support from GE Healthcare, Siemens Molecular Imaging, and Avid Radiopharmaceuticals and is a consultant for Bayer Pharmaceuticals. Dr Boeve's institution has received grants from the National Institutes of Health, Cephalon Inc, Allon Pharmaceuticals, the Mangurian Foundation, the Alzheimer's Association, and GE Healthcare and Dr Boeve has received royalties as the coeditor of the text Behavioral Neurology of Dementia and payment for development of educational presentations from the American Academy of Neurology. Dr Weiner has served on the following scientific advisory boards: 2009: Elan/Wyeth Alzheimer's Immunotherapy Program North American Advisory Board, Novartis Misfolded Protein Scientific Advisory Board Meeting, Banner Alzheimer's Institute Alzheimer's Prevention Initiative Advisory Board Meeting, and Research Advisory Committee on Gulf War Veterans' Illnesses; 2010: Lilly, Araclon and Institut Catala de Neurociencies Aplicades, Gulf War Veterans Illnesses Advisory Committee (VACO), and Biogen Idec; 2011: Pfizer. Dr Weiner has been a consultant for the following: 2009: Elan/Wyeth, Novartis, Forest, Ipsen, and Daiichi Sankyo, Inc; 2010: AstraZeneca, Araclon, Medivation/Pfizer, Ipsen, TauRx Therapeutics Ltd, Bayer Healthcare, Biogen Idec, Exonhit Therapeutics, SA, Servier, and Synarc; 2011: Pfizer. Dr Weiner has received funding for travel from the following: 2009: Elan/Wyeth Alzheimer's Immunotherapy Program North American Advisory Board, Alzheimer's Association, Forest, University of California, Davis, Tel-Aviv University Medical School, Colloquium Paris, Ipsen, Wenner-Gren Foundations, Social Security Administration, Korean Neurological Association, National Institutes of Health, Washington University at St Louis, Banner Alzheimer's Institute, Clinical Trials on Alzheimer's Disease, Veterans Affairs Central Office, Beijing Institute of Geriatrics, Innogenetics, and New York University; 2010: NeuroVigil, Inc, CHRU–Hopital Roger Salengro, Siemens, AstraZeneca, Geneva University Hospitals, Lilly, University of California, San Diego, ADNI, Paris University, Institut Catala de Neurociencies Aplicades, University of New Mexico School of Medicine, Ipsen, and CTAD (Clinical Trials on Alzheimer's Disease); 2011: Pfizer, AD Parkinson disease meeting, Paul Sabatier University, and Novartis. Dr Weiner has been on editorial advisory boards for AD and dementia and magnetic resonance imaging. Dr Weiner has received honoraria from the following: 2009: American Academy of Neurology and Ipsen; 2010: NeuroVigil, Inc, and Insitut Catala de Neurociencies Aplicades. Dr Weiner has received commercial entities research support from Merck and Avid and government entities research support from the Department of Defense and Veterans Affairs. Dr Weiner has stock options with Synarc and Elan. Dr Petersen is the chair of the Data Monitoring Committee for Pfizer, Inc, and Janssen Alzheimer Immunotherapy; is a consultant for Elan Pharmaceuticals and GE Healthcare; and gave a Continuing Medical Education presentation for Novartis. Dr Knopman serves as deputy editor for Neurology ; serves on a Data Safety Monitoring Board for Lilly Pharmaceuticals; is an investigator in clinical trials sponsored by Baxter, Elan Pharmaceuticals, and Forest Pharmaceuticals; and receives research support from the National Institutes of Health. The following organizations contributed to the Foundation for the National Institutes of Health and thus to the National Institute on Aging–funded ADNI: Abbott, Alzheimer's Association, Alzheimer's Drug Discovery Foundation, Anonymous Foundation, AstraZeneca, Bayer Healthcare, BioClinica, Inc (ADNI 2), Bristol-Myers Squibb, Cure Alzheimer's Fund, Eisai, Elan, Gene Network Sciences, Genentech, GE Healthcare, GlaxoSmithKline, Innogenetics, Johnson & Johnson, Eli Lilly & Company, Medpace, Merck, Novartis, Pfizer Inc, Roche Schering-Plough, Synarc, and Wyeth.
Funding/Support: This work was supported by National Institute on Aging grants R01AG11378, P50 AG16574, and U01 AG06786 and the ADNI, the Alexander Family Alzheimer's Disease Research Professorship of the Mayo Foundation, and the Robert H. and Clarice Smith Alzheimer's Disease Research Program of the Mayo Foundation.
Additional Contributions: Samantha Wille, BA, prepared the manuscript. Data used in the preparation of this article were obtained from the ADNI database (adni.loni.ucla.edu). As such, the investigators within the ADNI contributed to the design and implementation of ADNI and/or provided data but did not participate in analysis or writing of this report.