Accepted for Publication: October 27, 2011.
Published Online: March 5, 2012. doi:10.1001/archneurol.2011.2945
Author Contributions: Drs Rosas and Y. I. Chen contributed equally to this work. Dr Salat performed most of the statistical analyses. Study concept and design: Rosas, Y. I. Chen, Salat, Kwong, and Hersch. Acquisition of data: Rosas, Salat, Fox, and Hersch. Analysis and interpretation of data: Rosas, Y. I. Chen, Doros, N.-k. Chen, Kwong, and Hersch. Drafting of the manuscript: Rosas, Y. I. Chen, Doros, N.-k. Chen, and Hersch. Critical revision of the manuscript for important intellectual content: Rosas, Y. I. Chen, Doros, Salat, N.-k. Chen, Kwong, Fox, and Hersch. Statistical analysis: Rosas, Y. I. Chen, Doros, and Fox. Obtained funding: Rosas and Hersch. Administrative, technical, and material support: N.-k. Chen, Kwong, Bush, and Hersch. Study supervision: Rosas, Salat, N.-k. Chen, and Hersch.
Financial Disclosure: None reported.
Funding/Support: This research was supported in part by the National Institutes of Health, including the following grants: R01NS042861 and NS058793 from the National Institute for Neurological Disorders and Stroke (Drs Rosas, Y. I. Chen, Doros, Salat, and Hersch), AT000613 (Drs Rosas, Y. I. Chen, and Hersch) and P01AT002048 from the National Institute of Biomedical Imaging and Bioengineering (Dr Kwong), R21EB005690 from the National Center for Complementary and Alternative Medicine (Dr N.-k. Chen), HDSA Coalition for the CURE (Dr Fox), FD003359 from the Food and Drug Administration (Drs Rosas, Y. I. Chen, and Hersch), SFCA07-101 from the International Foundation for Gastrointestinal Disorders, NR010827 from the National Institute of Nursing Research (Dr Salat), and National Health and Medical Research Council (Dr Bush).
Additional Contributions: Alex Bender, BA; Keith Malarick, BA; and Susan Maya, BA, helped in recruiting study participants, and Tyler Triggs, BA, and Stephanie Lee, BA, provided technical assistance. We are grateful to our patients and family members who so generously contributed their time and energy to this work, without whom it would not have been possible.