Accepted for Publication: October 10, 2011.
Published Online: March 5, 2012. doi:10.1001/archneurol.2011.2463
Author Contributions:Study concept and design: Reitz, Conrad, and Mayeux. Acquisition of data: Conrad, Roszkowski, and Mayeux. Analysis and interpretation of data: Reitz, Conrad, and Rogers. Drafting of the manuscript: Reitz, Roszkowski, Rogers, and Mayeux. Critical revision of the manuscript for important intellectual content: Reitz, Conrad, and Mayeux. Statistical analysis: Reitz, Conrad, and Rogers. Obtained funding: Conrad and Mayeux. Administrative, technical, and material support: Conrad, Rogers, and Mayeux. Study supervision: Reitz, Conrad, and Mayeux.
Financial Disclosure: Dr Conrad reports that he has received grants from The Rosalinde and Arthur Gilbert Foundation/AFAR New Investigator Award in Alzheimer's Disease, Taub Institute for Research on Alzheimer's Disease and the Aging Brain, and Columbia University. Katherine Roszkowski's contribution was part of an independent student-mentor program with the Bronx High School of Science (Dr Susan Brauerman) and Columbia University (Dr Conrad). Data and samples from the NIALOAD Family Study, which receives government support under a cooperative agreement grant (U24AG026390), were also used in this study.
Funding/Support: This work was supported by grants R37-AG15473 and P01-AG07232 from the National Institute of Health and the National Institute on Aging, The Blanchett Hooker Rockefeller Foundation, The Charles S. Robertson Gift from the Banbury Fund, and The Merrill Lynch Foundation. Dr Reitz was further supported by a Paul B. Beeson Career Development Award (K23AG034550).
Additional Contributions: We thank contributors, including the AD centers, and the families whose participation made this work possible.