Accepted for Publication: March 8, 2012.
Published Online: May 14, 2012. doi:10.1001/archneurol.2012.650
Author Contributions:Study concept and design: Miller. Acquisition of data: Takada, Pimentel, DeJesus-Hernandez, Karydas, Thibodeau, Rutherford, Baker, Lomen-Hoerth, Rademakers, and Miller. Analysis and interpretation of data: Takada, Pimentel, DeJesus-Hernandez, Fong, Yokoyama, Karydas, Rutherford, Baker, Rademakers, and Miller. Drafting of the manuscript: Takada, Fong, Yokoyama, and Karydas. Critical revision of the manuscript for important intellectual content: Takada, Pimentel, DeJesus-Hernandez, Fong, Yokoyama, Thibodeau, Rutherford, Baker, Lomen-Hoerth, Rademakers, and Miller. Obtained funding: Rademakers. Administrative, technical, and material support: Takada, DeJesus-Hernandez, Karydas, Rutherford, and Baker. Study supervision: Rademakers and Miller.
Financial Disclosure: None reported.
Funding/Support: This work was supported in part by grants P50 AG016574, R01 NS065782, and R01 AG026251 from the National Institutes of Health and by the ALS Association (Dr Rademakers). Dr Miller is supported by grants P50 AG023501, P01 AG019724, and P50 AG1657303 from the National Institute on Aging, National Institutes of Health and by the Larry Hillblom Foundation and the State of California.
Online-Only Material: Listen to an author interview about this article, and others, at http://bit.ly/MT7xg4.
Additional Contributions: We thank this family for participating in our research.