Accepted for Publication: September 24, 2011.
Author Contributions:Study concept and design: Bonilla, Tanji, Turnbull, and Mahad. Acquisition of data: Lax, Campbell, Zambonin, Blakely, and Lassmann. Analysis and interpretation of data: Lax, Reeve, Ohno, Taylor, DiMauro, Jaros, Lassmann, Turnbull, and Mahad. Drafting of the manuscript: Lax and Mahad. Critical revision of the manuscript for important intellectual content: Campbell, Reeve, Ohno, Zambonin, Blakely, Taylor, Bonilla, Tanji, DiMauro, Jaros, Lassmann, and Turnbull. Obtained funding: Turnbull. Administrative, technical, and material support: Bonilla, Tanji, and DiMauro. Study supervision: Taylor, Jaros, Turnbull, and Mahad.
Financial Disclosure: None reported.
Funding/Support: The Wellcome Trust, Newcastle upon Tyne National Health Service Hospitals Charity, Multiple Sclerosis Society, UK National Institute for Health Research Biomedical Research Centre for Aging and Age-Related Diseases, Newcastle University Centre for Brain Aging and Vitality (supported by the Biotechnology and Biological Sciences Research Council, FRSRL, Economic and Social Research Council, and Medical Research Council project G0760718), and FWF Project P 19854 from the Wissenschaftsfonds Austria funded parts of this study. Part of this study was also supported by the Marriott Mitochondrial Disorders Clinical Research Fund.
Additional Information: Dr Bonilla died during this study, and we would like to dedicate this publication to his memory.
Additional Contributions: We thank Newcastle Brain Tissue Resource, Columbia University Medical Center (Department of Clinical Pathology), Medical University of Vienna (Center of Brain Research), and Medical Research Council HIV Brain and Tissue Bank (Edinburgh) for providing postmortem tissue. Trevor Booth, PhD, provided assistance with confocal microscopy. We are grateful to Bruce Trapp, PhD, Cleveland Clinic, for helpful comments.