Accepted for Publication: June 29, 2011.
Author Contributions:Study concept and design: Boxer and Neuhaus. Acquisition of data: Boxer, Garbutt, Seeley, Jafari, Hellmuth, and DeArmond. Analysis and interpretation of data: Boxer, Seeley, Jafari, Heuer, Mirsky, Hellmuth, Trojanowski, Huang, Neuhaus, and Miller. Drafting of the manuscript: Boxer, Garbutt, Mirsky, Trojanowski, and Neuhaus. Critical revision of the manuscript for important intellectual content: Boxer, Seeley, Jafari, Heuer, Hellmuth, Huang, DeArmond, Neuhaus, and Miller. Statistical analysis: Boxer, Jafari, Mirsky, and Neuhaus. Obtained funding: Boxer and Seeley. Administrative, technical, and material support: Boxer, Garbutt, Seeley, Jafari, Hellmuth, and Trojanowski. Study supervision: Boxer and Miller.
Financial Disclosure: Dr Boxer has been a consultant for Accera, Bristol-Myers Squibb, Genentech, Medivation, and TauRx. He has received research funding from Allon Therapeutics, Avid, Elan, Forest, Genentech, Janssen, Medivation, and Pfizer. He is funded by National Institutes of Health (NIH) grants R01AG038791 (principal investigator) and R01AG031278 (principal investigator), the Alzheimer's Drug Discovery Foundation, CurePSP, the Hellman Family Foundation, and the Tau Research Consortium. Dr Seeley has received research support from the NIH (grants R01AG033017 [principal investigator] and P50AG023501 [coinvestigator]), the James S. McDonnell Foundation, and the Consortium for Frontotemporal Dementia Research. Dr Trojanowski has received funding for travel and honoraria from Takeda; has received speaker honoraria from Pfizer; serves as associate editor of Alzheimer's & Dementia ; may accrue revenue on patents regarding modified avidin-biotin technique, method of stabilizing microtubules to treat AD, method of detecting abnormally phosphorylated tau, method of screening for AD or disease associated with the accumulation of paired helical filaments, compositions and methods for producing and using homogeneous neuronal cell transplants, rat comprising straight filaments in its brain, compositions and methods for producing and using homogeneous neuronal cell transplants to treat neurodegenerative disorders and brain and spinal cord injuries, diagnostic methods for AD by detection of multiple messenger RNAs, methods and compositions for determining lipid peroxidation levels in oxidant stress syndromes and diseases, compositions and methods for producing and using homogenous neuronal cell transplants, method of identifying, diagnosing, and treating α-synuclein–positive neurodegenerative disorders, mutation-specific functional impairments in distinct tau isoforms of hereditary FTD and parkinsonism linked to chromosome 17: genotype predicts phenotype, microtubule-stabilizing therapies for neurodegenerative disorders, and treatment for AD and related diseases with an antibody; and receives support from the NIH (National Institute on Aging grants P01AG09215-20 [principal investigator], P30AG10124-18 [principal investigator], P01AG17586-10 [Project 4 Leader], 1P01AG19724-07 [Core C Leader], 1AG024904-05 [co–principal investigator, Biomarker Core Laboratory], U01AG029213-01 [coinvestigator], and P30AG036468 [principal investigator]; National Institute of Neurological Disorders and Stroke grant P50NS053488-02 [principal investigator]; and grants RC2NS069368 and RC1AG035427 [principal investigator]) and the Marian S. Ware Alzheimer Program. Dr Miller serves on a scientific advisory board for the Alzheimer's Disease Clinical Study; serves as an editor for Neurocase and an associate editor of ADAD ; receives royalties from the publication of Behavioral Neurology of Dementia (Cambridge, 2009), Handbook of Neurology (Elsevier, 2009), and The Human Frontal Lobes (Guilford, 2008); serves as a consultant for Lundbeck, Elan, and Allon Therapeutics; serves on speaker's bureaus for Novartis and Pfizer; and receives research support from Novartis and the NIH (National Institute on Aging grants P50AG23501 and P01AG19724 [principal investigator]) and the State of California Alzheimer's Center.
Funding/Support: This work was supported by the NIH (grants R01 AG038791, R01 AG031278, P50 AG023501, and P01 AG019724), the John Douglas French Foundation, the Hellman Family Foundation, and the Larry L. Hillblom Foundation.