Accepted for Publication: July 22, 2011.
Author Contributions: Drs Crompton and Scheffer had full access to all the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis. Study concept and design: Crompton, Berkovic, and Scheffer. Acquisition of data: Crompton, Sadleir, Bellows, Arsov, Harty, Lawrence, Dunne, and Scheffer. Analysis and interpretation of data: Crompton, Bromhead, Bahlo, Arsov, Dunne, Berkovic, and Scheffer. Drafting of the manuscript: Crompton, Arsov, Dunne, and Scheffer. Critical revision of the manuscript for important intellectual content: Crompton, Sadleir, Bromhead, Bahlo, Bellows, Arsov, Harty, Lawrence, Dunne, Berkovic, and Scheffer. Statistical analysis: Bromhead, Bahlo, and Scheffer. Obtained funding: Berkovic and Scheffer. Administrative, technical, and material support: Sadleir, Bellows, Arsov, Harty, Lawrence, Dunne, and Scheffer. Study supervision: Crompton, Berkovic, and Scheffer.
Financial Disclosure: Dr Scheffer has served on scientific advisory boards for UCB and Janssen-Cilag EMEA; serves on the editorial boards of Annals of Neurology and Epileptic Disorders ; may accrue future revenue on pending patent WO61/010176 (filed in 2008) for Therapeutic Compound; has received speaker honoraria from Athena Diagnostics, UCB, Janssen-Cilag EMEA, and Eli Lilly and Company; has received funding for travel from Athena Diagnostics, UCB, and Janssen-Cilag EMEA; and receives and has received research support from the National Health and Medical Research Council of Australia, Health Research Council of New Zealand, The University of Melbourne, American Epilepsy Society, the Jack Brockhoff Foundation, the Shepherd Foundation, and the Perpetual Charitable Trustees.
Funding/Support: This work was supported by an Educational Fellowship Award from UCB Pharma (Dr Crompton), by a National Health and Medical Research Council of Australia Career Development Award (Dr Bahlo), and by program grants from the National Health and Medical Research Council of Australia (Drs Bahlo, Berkovic, and Scheffer).
Additional Contributions: Peter Bergin, FRACP, referred the first consultand; Winita Hardikar, PhD, referred the second consultand; Ann-Maree Saunders and Tracey Austin performed EEGs; Elizabeth Walker, FRACP, facilitated clinical study of family members in Auckland, New Zealand; Alice-Ann Sullivan, FRACP, facilitated clinical study of family members in Brisbane, Australia; and Kate Tuck and Bruce Day, FRACP, assisted with EEG-EMG back averaging. We acknowledge the family for their generous participation in the study.