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From JAMA |

Treatment of Arteriovenous Malformations A Meta-analysis

E. Steve Roach, MD
Arch Neurol. 2012;69(4):521-522. doi:10.1001/archneurol.2011.3514.
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Arteriovenous malformations (AVMs) are lesions characterized by direct connection of arteries to veins without an intervening capillary phase, resulting in shunting of arterial blood directly into the venous circulation.1 The prevalence of intracranial AVMs is about 18 per 100 000 adults.2 About half of symptomatic intracranial AVMs are identified after a brain hemorrhage, and another one-third are discovered because of seizures.35 Intracerebral hemorrhage likely occurs because the dilated, thin-walled vessels of the AVM cannot withstand the effects of the arterial blood pressure. Large shunts can also divert enough blood from the surrounding brain to cause ischemia of the adjacent brain tissue, sometimes resulting in seizures or cognitive impairment.


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