Accepted for Publication: June 20, 2011.
Published Online: January 2, 2012. doi:10.1001/archneurol.2011.670
Author Contributions: Study concept and design: Beiser, Seshadri, and Schaefer. Acquisition of data: Van Himbergen, Beiser, Ai, Seshadri, Otokozawa, Au, Wolf, and Schaefer. Analysis and interpretation of data: Van Himbergen, Beiser, Ai, Seshadri, Otokozawa, and Thongtang. Drafting of the manuscript: Van Himbergen, Seshadri, Thongtang, and Schaefer. Critical revision of the manuscript for important intellectual content: Van Himbergen, Beiser, Ai, Seshadri, Otokozawa, Au, Thongtang, Wolf, and Schaefer. Statistical analysis: Van Himbergen, Beiser, and Thongtang. Obtained funding: Seshadri. Administrative, technical, and material support: Ai, Otokozawa, Au, Thongtang, Wolf, and Schaefer. Study supervision: Seshadri.
Financial Disclosure: Dr Van Himbergen was supported by a research grant from Unilever Food and Health Research Institute, Unilever R&D, Vlaardingen, the Netherlands. Dr Ai and Ms Otokozawa were supported by research fellowships from Denka Seiken Co, Tokyo, Japan, and Kyowa Medex Co, Tokyo.
Funding/Support: Dr Thongtang was supported by a research fellowship from Siriraj Hospital, Mahidol University, Bangkok, Thailand. Dr Schaefer was supported by grants R01 HL-60935, HL 74753, and PO50HL083813 from the National Institutes of Health and contract 53-3K-06 from the US Department of Agriculture Agriculture Research Service. This work was also supported by the Framingham Heart Study's National Heart, Lung, and Blood Institute contract N01-HC-25195 and by National Institute of Neurological Disorders and Stroke grant R01 NS17950 and National Institute on Aging grants R01 AG16495, AG08122, AG033040, AG033193 and AG031287, and P30AG013846.
Disclaimer: The content is solely the responsibility of the authors and does not necessarily represent the official views of Unilever, the National Heart, Lung, and Blood Institute, National Institute of Neurological Disorders and Stroke, National Institute on Aging, or National Institutes of Health.
Additional Information: The Framingham Dementia Study was planned and is being carried out by Drs Wolf, Au, Beiser, and Seshadri. The selection of the assays for this were made by Dr Schaefer, and the assays for this study were measured by Dr Ai and Ms Otokozawa.