Accepted for Publication: August 3, 2011.
Published Online: October 10, 2011. doi:10.1001/archneurol.2011.1426
Author Contributions:Study concept and design: Kinkel, O’Connor, and Simon. Acquisition of data: Kinkel, Kollman, Skaramagas, O’Connor, and Simon. Analysis and interpretation of data: Kinkel, Dontchev, Kollman, O’Connor, and Simon. Drafting of the manuscript: Kinkel, Dontchev, O’Connor, and Simon. Critical revision of the manuscript for important intellectual content: Kinkel, Kollman, Skaramagas, O’Connor, and Simon. Statistical analysis: Kinkel, Dontchev, and Kollman. Obtained funding: Kinkel. Administrative, technical, and material support: Kinkel, Skaramagas, and Simon. Study supervision: Kinkel and Kollman.
CHAMPIONS Investigators: Douglas Arnold, MD, Montreal Neurological Institute, Quebec, Canada; Staley Brod, MD, University of Texas Health Science Center at Houston; Pierre Duquette, MD, Hospital Notre Dame, Montreal, Quebec, Canada; Eric Eggenberger, MD, Michigan State University, East Lansing; Warren Felton, MD, Virginia Commonwealth University, Richmond; Robert Fox, MD, Cleveland Clinic Foundation, Ohio; Mark Freedman, MD, Ottawa General Hospital, Ontario, Canada; Steven Galetta, MD, University of Pennsylvania Medical Center, Philadelphia; Andrew Goodman, MD, University of Rochester, New York; Joseph Guarnaccia, MD, MS Treatment Center, Griffin Hospital, Derby, CT; Stanley Hashimoto, MD, University of British Columbia, Vancouver, Canada; Michael Kaufman, MD, Carolinas Medical Center, Charlotte, NC; Lawrence Kerson, MD, The Neurology Group, Norristown, PA; Thomas Murray, MD, Queen Elizabeth II Health Sciences Centre, Centre for Clinical Research, Halifax, Nova Scotia, Canada; Paul W. O’Connor, MD, University of Toronto, Ontario, Canada; Kottil Rammohan, MD, Ohio State University, Columbus; Merrell Reiss, MD, Beta Research, Inc, Westmont, IL; Loren Rolak, MD, Marshfield Clinic, Wisconsin; Thomas Scott, MD, Allegheny Neurological Associates, Pittsburgh, PA; John Selhorst, MD, St Louis University, Missouri; William Stuart, MD, MS Center of Atlanta, Georgia; Stephen Thurston, MD, Neurological Associates, Inc, Richmond, VA; Michael Wall, MD, University of Iowa, Iowa City; Bianca Weinstock-Guttman, MD, Buffalo General Hospital, Jacobs Neurological Institute, New York.
Financial Disclosure: Dr Kinkel has received either personal compensation or financial support from his institution for activities in collaboration with pharmaceutical companies (including Acorda, Avanir, Biogen Idec, and Teva) that develop products for MS. He has also received grant support from the National MS Society as well as support as section editor of Reviews in Neurological Diseases. Dr O'Connor has received either personal compensation or financial support from his institution for activities in collaboration with pharmaceutical companies (including Actelion, Biogen Idec, Celgene, sanofi-aventis, EMD Serono, Abbott, Teva, Bayer, BioMS Technology Corp, Genentech, Lilly, Roche, and Novartis) that develop products for MS. He has received grant support from the MS Society of Canada and Direct-MS. Dr Simon has received either personal compensation or financial support from his institution for activities related to pharmaceutical companies (including Genzyme, Protein Design Labs, Pfizer, Genentech, Bristol-Myers Squibb, Artielle Immunotherapeutics, BioMS Technology Corp, and Biogen Idec) that develop products for MS.
Funding/Support: This study was funded by Biogen Idec.