Accepted for Publication: March 14, 2011.
Author Contributions:Study concept and design: Logue, Griffith, Obisesan, Shatz, Borenstein, Cupples, Lunetta, Fallin, Baldwin, and Farrer. Acquisition of data: Green, Go, Obisesan, Shatz, Borenstein, Fallin, Baldwin, and Farrer. Analysis and interpretation of data: Logue, Schu, Vardarajan, Buros, Green, Go, Cupples, Lunetta, and Farrer. Drafting of the manuscript: Logue, Schu, Buros, Green, Baldwin, and Farrer. Critical revision of the manuscript for important intellectual content: Logue, Vardarajan, Go, Griffith, Obisesan, Shatz, Borenstein, Cupples, Lunetta, Fallin, Baldwin, and Farrer. Statistical analysis: Logue, Schu, Vardarajan, Buros, Green, Cupples, Lunetta, Fallin, and Farrer. Obtained funding: Go, Shatz, Borenstein, and Farrer. Administrative, technical, and material support: Schu, Buros, Green, Obisesan, Borenstein, Baldwin, and Farrer. Study supervision: Logue, Obisesan, Borenstein, Lunetta, Fallin, Baldwin, and Farrer.
Group Members: Members of the MIRAGE Study Group include Drs Farrer, Green, Baldwin, Cupples, Lunetta, and Logue (Boston University); Dr Griffith, Abimbola Akomolafe, MD, MPH, Angela Ashley, MD, Lorin Freedman, MD, and Elizabeth Ofili, MD (Morehouse School of Medicine); Helena Chui, MD (University of Southern California, Los Angeles); Ranjan Duara, MD (Mt Sinai Medical Center, Miami, Florida); Tatiana Foroud, PhD, and Martin Farlow, MD (Indiana University School of Medicine, Indianapolis); Robert Friedland, MD (University of Louisville, Louisville, Kentucky); Dr Go and Lindy Harrell, MD, PhD (University of Alabama–Birmingham); Alexander Kurz, MD (Technical University, Munich, Germany); Dr Obisesan (Howard University); Helen Petrovitch, MD, and Lon White, MD (Pacific Health Research Institute, Honolulu, Hawaii); Marwan Sabbagh, MD (Sun Health Research Institute, Sun City, Arizona); Dessa Sadovnick, PhD (University of British Columbia, Vancouver); and Magda Tsolaki, MD (University of Aristotle, Thessaloniki, Greece).
Financial Disclosure: None reported.
Funding/Support: This study was supported by grants R01-AG09029, R01-AG025259, R01-HG02213, R01-HG005092, 5R01AG020688, K24-AG027841, P30-AG13846, P30-AG10129, and K01 MH076100 from the National Institutes of Health.
Online-Only Material: The eTables, eMethods, and eAppendix are available at http://www.bumc.bu.edu/genetics/genetics-people/results-2.
Additional Contributions: The GenerAAtions Study Group provided input in design, implementation, and consensus diagnosis efforts, including Hugh Hendrie, MD, and Fred Unverzagt, PhD (Indiana University), and Susan Bassett, PhD (Johns Hopkins). Michael Wake, MPH, MSW, provided project coordination.