Accepted for Publication: February 16, 2011.
Author Contributions: All authors had full access to all the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis. Study concept and design: Roe. Acquisition of data: Fagan, Grant, Benzinger, Mintun, and Morris. Analysis and interpretation of data: Roe, Marcus, and Holtzman. Drafting of the manuscript: Roe and Marcus. Critical revision of the manuscript for important intellectual content: Roe, Fagan, Grant, Benzinger, Mintun, Holtzman, and Morris. Statistical analysis: Roe. Obtained funding: Holtzman and Morris. Administrative, technical, and material support: Fagan, Grant, Marcus, Benzinger, Mintun, Holtzman, and Morris. Study supervision: Benzinger and Morris.
Financial Disclosure: Dr Benzinger has served as a consultant to Biomedical Systems Inc and for ICON Medical Imaging and has received research funding from Avid Radiopharmaceuticals. Dr Holtzman is on the scientific advisory boards of Satori, En Vivo, and C2N Diagnostics and has consulted for Pfizer, Bristol-Myers Squibb, and Innogenetics. Dr Morris has participated or is currently participating in clinical trials of antidementia drugs sponsored by Elan, Eli Lilly & Co, and Wyeth and has served as a consultant for or has received speaking honoraria from AstraZeneca, Bristol-Myers Squibb, Eisai, Elan/Janssen Alzheimer Immunotherapy Program, Genentech, Eli Lilly & Co, Merck, Novartis, Otsuka Pharmaceuticals, Pfizer/Wyeth, and Schering-Plough.
Funding/Support: This work was supported by grant P30 NS057105 from the National Institute of Neurological Disorders and Stroke; grants P50 AG005681, P01 AG003991, and P01 AG026276 from the National Institute on Aging; grants 1UL1RR024992 from the National Center for Research Resources; and the Charles F. and Joanne Knight Alzheimer’s Research Initiative of the Washington University Alzheimer Disease Research Center.
Additional Contributions: We thank the participants, investigators, and staff of the Alzheimer Disease Research Center Clinical (participant assessments) and Genetics (genotyping) Cores and the investigators and staff of the Biomarker Core for the Adult Children Study (P01 AG026276) for CSF analytes.