Accepted for Publication: October 28, 2010.
Author Contributions:Study concept and design: Sabuncu, Desikan, Liu, Reuter, and Weiner. Acquisition of data: Weiner and Sperling. Analysis and interpretation of data: Sabuncu, Desikan, Sepulcre, Yeo, Schmansky, Buckner, Sperling, and Fischl. Drafting of the manuscript: Sabuncu, Desikan, and Fischl. Critical revision of the manuscript for important intellectual content: Sabuncu, Desikan, Sepulcre, Yeo, Liu, Schmansky, Reuter, Weiner, Buckner, Sperling, and Fischl. Statistical analysis: Sabuncu, Yeo, Buckner, and Fischl. Obtained funding: Sabuncu, Weiner, and Fischl. Administrative, technical, and material support: Sabuncu, Liu, Schmansky, Reuter, Weiner, and Fischl. Study supervision: Desikan, Buckner, Sperling, and Fischl.
Financial Disclosure: Dr Weiner has served on scientific advisory boards for CoMentis Inc, Neurochem International Limited, Elan and Wyeth Alzheimer's Immunotherapy Program (North America), Novartis International AG, Banner Alzheimer's Institute Alzheimer's Prevention Initiative, Eli Lilly and Company, Araclon Biotech, Institut Català de Neurociències Aplicades, Research Advisory Committee on Gulf War Veterans' Illnesses, Biogen Idec, Pfizer Global Research & Development, Forest Laboratories Inc, Medivation Inc, Bayer Schering-Plough Corporation, Elan Pharmaceuticals Inc, Ipsen Group, Daiichi Sankyo Inc, AstraZeneca AB, TauRx Therapeutics Ltd, Bayer Healthcare, Exonhit Therapeutics SA, Servier Laboratories, and SYNARC Inc. He has received funding for travel from the Foundation for the National Institutes of Health (NIH); Avid Radiopharmaceuticals Inc; GE Healthcare Japan; the Research Association for Biotechnology; Pfizer Global Research & Development; Forest Laboratories Inc; Alliance Médicale et Scientifique; the National Multiple Sclerosis Society; Bayer Healthcare; The Johns Hopkins University; the Alzheimer's Association; the Telemedicine & Advanced Technology Research Center; the University of Pittsburgh; the Neuroscience Early Stage Research Training Program; the Rotman Research Institute; the Wien Center for Alzheimer's Disease and Memory Disorders; Mount Sinai Medical Center; the Society of Photographic Instrumentation Engineers; the Montreal Neurological Institute and Hospital of McGill University; the Michael J. Fox Foundation for Parkinson's Research; Elan and Wyeth Alzheimer's Immunotherapy Program (North America); Forest Laboratories Inc; the University of California, Davis; Tel Aviv University Medical School; Colloquium Paris; Ipsen Group; the Wenner-Gren Foundation; the US Social Security Administration; the Korean Neurological Association; the NIH; Washington University in St Louis; Banner Alzheimer's Institute; Clinical Trials on Alzheimer's Disease; the Veterans Affairs Central Office; the Beijing Institute of Geriatrics; Innogenetics NV; New York University; NeuroVigil Inc; Centre Hospitalier Régional Universitaire–Hôpital Roger Salengro; Siemens AG; AstraZeneca AB; Geneva University Hospitals; Eli Lilly and Company; Hôpital Pitié-Salpêtrière (Assistance Publique–Hôpitaux de Paris); Institut Català de Neurociències Aplicades; the University of New Mexico School of Medicine; and Clinical Trials on Alzheimer's Disease. He has served on the editorial board for Alzheimer's & Dementia, has received honoraria from GE Healthcare Japan, Research Association for Biotechnology, The Johns Hopkins University, the Rotman Research Institute, the American Academy of Neurology, Ipsen Group, NeuroVigil Inc, and Institut Català de Neurociències Aplicades; has received commercial entities research support from Merck & Co Inc and Avid Radiopharmaceuticals Inc; has received government entities research support from the NIH, the US Department of Defense, and the US Department of Veterans Affairs; and has stock options in SYNARC Inc and Elan Pharmaceuticals Inc.
Funding/Support: Data collection and sharing for this project was funded by the ADNI and NIH grant U01 AG024904 (principal investigator [PI], Dr Weiner). The ADNI is funded by the National Institute on Aging, by the National Institute of Biomedical Imaging and Bioengineering, and through generous contributions from Abbott Laboratories, AstraZeneca AB, Bayer Schering Pharma AG, Bristol-Myers Squibb, Eisai Global Clinical Development, Elan Corporation plc, Genentech Inc, GE Healthcare, GlaxoSmithKline plc, Innogenetics NV, Johnson & Johnson Services Inc, Eli Lilly and Company, Medpace Inc, Merck & Co Inc, Novartis International AG, Pfizer Inc, F. Hoffman-La Roche Ltd, Schering-Plough Corporation, SYNARC Inc, and Wyeth Pharmaceuticals, as well as nonprofit partners the Alzheimer's Association and the Alzheimer's Drug Discovery Foundation, with participation from the US Food and Drug Administration. Private sector contributions to the ADNI are facilitated by the Foundation for the NIH. The grantee organization is the Northern California Institute for Research and Education Inc, and the study is coordinated by the Alzheimer's Disease Cooperative Study at the University of California, San Diego. The ADNI data are disseminated by the Laboratory of Neuro Imaging at the University of California, Los Angeles. Further support for this research was provided in part by grant P41-RR14075 from the National Center for Research Resources (Dr Fischl [PI, Bruce Rosen, MD, PhD]), grant R01EB006758 from the National Institute for Biomedical Imaging and Bioengineering (PI, Dr Fischl), grant AG022381 from the National Institute on Aging (Dr Fischl [PI, William S. Kremen, PhD]), grant R01 NS052585-01 from the National Institute for Neurological Disorders and Stroke (PI, Dr Fischl), grant P41-RR14075 from the National Center for Research Resources (Dr Fischl [PI, Dr Rosen]), grants BIRN002 and U24 RR021382 from the National Center for Research Resources Biomedical Informatics Research Network Morphometric Project (Dr Fischl [PI, Dr Rosen]), grant RC1 AT005728-01 from the National Center for Alternative Medicine (Dr Fischl [PI, Dr Rosen]), grant R01EB006758 from the National Institute for Biomedical Imaging and Bioengineering (PI, Dr Fischl), and grant R01 NS052585-01 from the National Institute for Neurological Disorders and Stroke (PI, Dr Fischl); from Shared Instrumentation Grants 1S10RR023401, 1S10RR019, and 1S10RR023043; and The Autism & Dyslexia Project funded by the Ellison Medical Foundation. Dr Sabuncu receives support from a KL2 Medical Research Investigator Training grant awarded via Harvard Catalyst, The Harvard Clinical and Translational Science Center (NIH grant 1KL2RR025757-01 and financial contributions from Harvard University and its affiliated academic health care centers).
Additional Contributions: Data used in the preparation of this article were obtained from the ADNI database (http://adni.loni.ucla.edu/). As such, the investigators within the ADNI contributed to the design and implementation of the ADNI and/or provided data but did not participate in the analysis or writing of this report.