Accepted for Publication: June 7, 2011.
Author Contributions:Study concept and design: Irizarry, Raman, Thomas, Ishihara, Weil, and Aisen. Acquisition of data: Emond, Sano, Quinn, Tariot, Galasko, and Aisen. Analysis and interpretation of data: Irizarry, Jin, He, Emond, Raman, Thomas, Tariot, Galasko, Ishihara, and Aisen. Drafting of the manuscript: Irizarry, He, Emond, and Ishihara. Critical revision of the manuscript for important intellectual content: Irizarry, Jin, Raman, Thomas, Sano, Quinn, Tariot, Galasko, Ishihara, Weil, and Aisen. Statistical analysis: Irizarry, Jin, He, Emond, Raman, and Thomas. Obtained funding: Sano. Administrative, technical, and material support: Sano, Tariot, and Aisen. Study supervision: Irizarry, Thomas, Tariot, Weil, and Aisen.
Financial Disclosure: Drs Irizarry and Ishihara are stock and options–holding employees of GlaxoSmithKline. During the course of the project, Dr Tariot served as a consultant to Abbott Laboratories, and the Banner Alzheimer's Institute received support as an investigative site in a multicenter Abbott Laboratories–sponsored trial of a different antidementia agent. He also received grant or research support from AstraZeneca, Avid, Baxter, Elan Pharmaceuticals, GlaxoSmithKline, Johnson & Johnson, Eli Lilly, Medivation, Merck, Pfizer, Takeda Pharmaceuticals, and Wyeth. He also served as a consultant for or received consulting fees from AC Immune, Acadia, Adamas, Allergan, AstraZeneca, Avid, Baxter, Bristol-Myers Squibb, Eisai, Elan, Eli Lilly, Epix, Forest, GlaxoSmithKline, Medavante, Medivation, Merck, Myriad, Pfizer, Roche, Sanofi-Aventis, Schering-Plough, Toyama, Transition Therapeutics, Worldwide Clinical Trials, and Wyeth. He also received stock options from Adamas and Medavante. Dr Weil was a stock and options–holding employee of GlaxoSmithKline during the time of this study.
Funding/Support: The analysis in this article was supported by GlaxoSmithKline. The clinical trials were supported by grants NIH U01AG10483 and R01ES010804 from the Alzheimer's Disease Cooperative Study Group.
This article was corrected for errors on March 28, 2012.