Accepted for Publication: April 7, 2011.
Author Contributions:Study concept and design: Small, Siddarth, and Kepe. Acquisition of data: Small, Kepe, Ercoli, Burggren, Bookheimer, Miller, Kim, and Lavretsky. Analysis and interpretation of data: Small, Siddarth, Kepe, Ercoli, Burggren, Bookheimer, Huang, and Barrio. Drafting of the manuscript: Small, Siddarth, Miller, Kim, Lavretsky, and Barrio. Critical revision of the manuscript for important intellectual content: Small, Siddarth, Kepe, Ercoli, Burggren, Bookheimer, Lavretsky, Huang, and Barrio. Statistical analysis: Siddarth and Barrio. Obtained funding: Small, Barrio, Ercoli, and Lavretsky. Administrative, technical, and material support: Small, Ercoli, Burggren, Bookheimer, Miller, Kim, Lavretsky, and Huang. Study supervision: Small, Burggren, and Barrio.
Financial Disclosure: The University of California, Los Angeles, owns a US patent (6,274,119) entitled “Methods for Labeling β-Amyloid Plaques and Neurofibrillary Tangles” that uses the approach outlined in this article. Drs Small, Huang, and Barrio are among the inventors, have received royalties, and may receive royalties on future sales. Dr Small reports having served as a consultant and/or having received lecture fees from Dakim, Eisai, Forest, Lily, Medivation, Novartis, and Pfizer. Dr Small also reports having received stock options from Dakim. Dr Lavretsky reports having received lecture fees from Eisai, Janssen, and Pfizer and having received a grant from Forest. Dr Huang reports having received lecture fees from GlaxoSmithKline. Dr Barrio reports having served as a consultant and having received lecture fees from Nihon Medi-Physics Co, Bristol-Myers Squibb, PETNet Pharmaceuticals, and Siemens. Drs Ercoli, Siddarth, Burggren, Kepe, Kim, Miller, and Bookheimer have no financial conflicts of interest.
Funding/Support: This study was supported by grants P01-AG025831, AG13308, P50 AG 16570, MH/AG58156, MH52453, AG10123, and M01-RR00865 from the National Institutes of Health; contract DE-FC03-87-ER60615 from the Department of Energy; General Clinical Research Centers Program; the Fran and Ray Stark Foundation Fund for Alzheimer's Disease Research; the Ahmanson Foundation; the Larry L. Hillblom Foundation; the Lovelace Foundation; the Sence Foundation; the McMahan Foundation; the Judith Olenick Elgart Fund for Research on Brain Aging; and the Elizabeth and Thomas Plott Endowment in Gerontology.
Role of the Sponsors: No company provided support of any kind for this study.
Previous Presentations: Presented in part at the American College of Neuropsychopharmacology Annual Meeting; December 9, 2009; Hollywood, Florida.
Additional Contributions: Anel Dzmura, BA, and Colin Shinn, MA, provided help with study participant recruitment, data management, and study coordination, and Gerald Timbol and Anasheh Halabi provided help with image processing.