Accepted for Publication: June 27, 2011.
Published Online: September 12, 2011. doi:10.1001/archneurol.2011.228
Author Contributions: Dr Hackam had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis. Study concept and design: Hackam, Juurlink, Mamdani, Paterson, and Kapral. Acquisition of data: Hackam, Huang, and Kapral. Analysis and interpretation of data: Hackam, Austin, Huang, Mamdani, Paterson, Hachinski, Li, and Kapral. Drafting of the manuscript: Hackam and Kapral. Critical revision of the manuscript for important intellectual content: Hackam, Austin, Huang, Juurlink, Mamdani, Paterson, Hachinski, Li, and Kapral. Statistical analysis: Austin, Huang, Juurlink, Mamdani, and Li. Obtained funding: Hackam and Kapral. Study supervision: Hackam, Hachinski, and Kapral.
Financial Disclosure: Dr Mamdani has received honoraria for serving on advisory boards for Pfizer, Eli Lilly and Co, Novartis, GlaxoSmithKline, and Boehringer Ingelheim.
Funding/Support: This study was supported by a peer-reviewed grant-in-aid from the Physicians' Services Incorporated Foundation (a nonprofit medical research charity). Dr Hackam was supported by a Canadian Institutes for Health Research New Investigator Award. Dr Austin was supported by a Career Investigator Award from the Heart and Stroke Foundation of Ontario. Dr Kapral was supported by a Canadian Institutes for Health Research New Investigator Award and also receives support from the Canadian Stroke Network. This project was conducted at the Institute for Clinical Evaluative Sciences, which is supported by an annual grant from the Ontario Ministry of Health and Long-Term Care.
Role of the Sponsor: The sponsors had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; or preparation, review, or approval of the manuscript.
Disclaimer: Opinions, results, and conclusions in this article are those of the authors and are independent from the funding sources. No endorsement by the Institute for Clinical Evaluative Sciences or the Ontario Ministry of Health and Long-Term Care is intended or should be inferred.
Additional Contributions: Nick Daneman, MD, MSc, Amit Garg, MD, PhD, Marko Mrkobrada, MD, Donald Redelmeier, MD, MSHSR, and Matthew Weir, MD, provided helpful comments on the manuscript; these individuals were not compensated for their assistance.