Accepted for Publication: March 17, 2011.
Author Contributions:Study concept and design: Ances, Benzinger, and Clifford. Acquisition of data: Ances, Benzinger, Christensen, Thomas, Teshome, Venkat, and Aldea. Analysis and interpretation of data: Ances, Benzinger, Christensen, Venkat, Fagan, Holtzman, Morris, and Clifford. Drafting of the manuscript: Ances. Critical revision of the manuscript for important intellectual content: Benzinger, Fagan, Morris, and Clifford. Statistical analysis: Ances, Thomas, and Venkat. Obtained funding: Ances and Morris. Administrative, technical, and material support: Christensen, Aldea, and Teshome. Study supervision: Ances, Fagan, Holtzman, Morris, and Clifford.
Financial Disclosure: Dr Ances is currently participating in a clinical trial of antidementia drugs sponsored by Pfizer. Dr Benzinger consults for Biomedical Systems Inc and ICON Medical Imaging and receives research support from Avid Radiopharmaceuticals. Dr Holtzman reports consulting for Pfizer, Bristol-Myers Squibb, and Innogenetics and is on the scientific advisory board of En Vivo, Satori, and C2N Diagnostics. Dr Morris is currently participating in clinical trials of antidementia drugs sponsored by Janssen, Pfizer, and Eli Lilly Company. He reports consulting for AstraZeneca, Bristol-Myers Squibb, Eisai, Elan/Janssen Alzheimer Immunotherapy Program, Genentech, Lilly, Merck, Novartis, Otsuka Pharmaceuticals, Pfizer/Wyeth, and Schering Plough. Dr Clifford reports serving on data monitoring committees and/or as a scientific adviser to Biogen Idec, Elan, Pfizer, Roche, Forest Labs, Genentech, GlaxoSmithKline, Millennium, Schering Plough, Bristol- Myers Squibb, and Genzyme with research support from Pfizer, Schering Plough, Bavarian Nordic, NeurogesX, GlaxoSmithKline, Tibotec, Boehringer Ingelheim, Gilead, and Biogen Idec.
Funding/Support: This study was supported by pilot grant 3255 P50AG05681 from the ADRC (Drs Ances and Morris), grant K23MH081786 from the National Institute of Mental Health (Dr Ances), grant R01NR012657 from the National Institute of Nursing Research (Dr Ances), grant DF10052 from the Dana Foundation (Dr Ances), American Roentgen Ray Society Scholar Award (Dr Benzinger), grant 22005 from the National Institute of Mental Health (Central Nervous System Highly Activated Retroviral Therapy Effects Research) (Drs Ances and Clifford), and grants P01-AG026276 and P01-AG03991 from the National Institutes of Health (Dr Morris).
Additional Contribution: We acknowledge the assistance of the ADRC clinical, genetics, imaging, and psychometrics cores.