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Original Contributions |

Daclizumab Use in Patients With Pediatric Multiple Sclerosis

Mark P. Gorman, MD; Jan-Mendelt Tillema, MD; Annika M. Ciliax, MD; Charles R. G. Guttmann, MD; Tanuja Chitnis, MD
Arch Neurol. 2012;69(1):78-81. doi:10.1001/archneurol.2011.581.
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Background Daclizumab, a humanized monoclonal antibody specific for the interleukin 2 receptor α chain, reduces clinical and magnetic resonance imaging disease activity in patients with adult-onset multiple sclerosis (MS) as monotherapy or add-on therapy with interferon.

Objective To report the use of daclizumab in pediatric-onset MS.

Design Case series.

Setting Two comprehensive pediatric MS centers.

Patients Seven patients with pediatric-onset MS with clinical and magnetic resonance imaging disease activity despite first-line disease-modifying therapy.

Intervention Intravenous daclizumab, 1 mg/kg monthly.

Main Outcome Measures Annualized relapse rates, Expanded Disability Status Scale scores, contrast-enhancing lesions, and adverse effects.

Results Treatment with daclizumab, primarily combined with interferon, was associated with reductions in annualized relapse rates and contrast-enhancing lesions and with reduction or stabilization of Expanded Disability Status Scale scores in each patient. However, 4 patients had relapses and new contrast-enhancing lesions during daclizumab treatment. No significant adverse effects occurred.

Conclusion Daclizumab may be a safe and at least partially effective treatment option for patients with pediatric-onset MS with disease activity despite first-line disease-modifying therapy.

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