0
We're unable to sign you in at this time. Please try again in a few minutes.
Retry
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
Retry
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Editorials |

Statin Use and Intracerebral Hemorrhage:  Evidence for Safety in Recurrent Stroke Prevention?

Philip B. Gorelick, MD, MPH
Arch Neurol. 2012;69(1):13-16. doi:10.1001/archneurol.2011.234.
Text Size: A A A
Published online

Extract

The 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors, or “statins,” are frequently prescribed in clinical practice for the prevention of stroke and cardiovascular disease.1 According to a nongeneric drug retail sales' report of the top 200 drugs sold in 2009, one of the statins ranked number 1 and another ranked number 14 in overall sales.2 Statins are multimechanistic drugs with lipid-lowering properties and beneficial non–lipid-lowering effects such as modification of endothelial function, inflammatory responses, atherosclerotic plaque vulnerability, and thrombus formation. Although generally well tolerated, statins may be associated with adverse events such as muscle aches, hepatitis or hepatotoxicity, myopathy, and other complications.1 Furthermore, a safety announcement from the US Food and Drug Administration recently informed the public about the risk of muscle injury in patients taking the highest approved dose of simvastatin (80 mg),3 and based on a pooled analysis of data from 5 statin trials, concern has been raised that intensive-dose statin therapy may be associated with an increased risk of diabetes mellitus.4

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

First Page Preview

View Large
First page PDF preview

First Page Preview

View Large
First page PDF preview

Figures

Tables

References

Correspondence

CME
Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
Submit a Comment

Multimedia

Some tools below are only available to our subscribers or users with an online account.

Web of Science® Times Cited: 2

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

Related Content

Customize your page view by dragging & repositioning the boxes below.

See Also...
Articles Related By Topic
Related Collections
Jobs
JAMAevidence.com

Users' Guides to the Medical Literature
Clinical Scenario

Users' Guides to the Medical Literature
Statin Dosing and LDL Levels

brightcove.createExperiences();