Accepted for Publication: May 6, 2011.
Author Contributions:Study concept and design: Wang. Acquisition of data: Lee, Meng, Blaivas, and Wang. Analysis and interpretation of data: Lee, Meng, Elmadhoun, Blaivas, and Wang. Drafting of manuscript: Elmadhoun and Wang. Critical revision of the manuscript for important intellectual content: Lee, Meng, Elmadhoun, Blaivas, and Wang. Obtaining funding: Wang. Administrative, technical, and material support: Lee, Meng, Elmadhoun, Blaivas, and Wang. Study supervision: Wang.
Financial Disclosure: None reported.
Funding/Support: This study was supported in part by grants NS052681, NS054724, and NS062816 from the National Institutes of Health (Dr Wang). The Alzheimer's Disease Research Center is supported by grant P50-AG08671 and supplied control tissues for studies.
Additional Contributions: Jimo Borjigin, PhD, provided helpful discussions and Andrew Lieberman, MD, PhD, of the Michigan Alzheimer's Disease Research Center, provided patient samples. Nancy McAnsh of the University of Michigan Comprehensive Cancer Center provided excellent technical support for experiments. We thank the patients and families who have donated precious tissue resources that were used in this study.