We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Correspondence |

Parkinson Disease and Vitamin D: An Interplay Between Genes and the Environment?

Gabriele C. DeLuca, MD, DPhil; Grace Li, BA; Sreeram Ramagopalan, DPhil
Arch Neurol. 2011;68(12):1615-1616. doi:10.1001/archneurol.2011.1078.
Text Size: A A A
Published online


We read with interest the article by Evatt et al1 on the prevalence of hypovitaminosis D status in patients with early Parkinson disease. Epidemiologically, a season of birth effect and a latitude effect have been observed for this disorder.2,3 Genetic studies have shown polymorphisms in the VDR gene that are associated with the risk of Parkinson disease.4 Genome-wide association studies have identified several candidate genes that are associated with risk of Parkinson disease, several of which have VDR binding associated with them, raising the possibility that vitamin D may influence their expression.5 These potential vitamin D–regulated genes in Parkinson disease have important roles to play in the nervous system, including nigrostriatal dopaminergic neurotransmission, neurogenesis, neurite outgrowth, and neural ectodermal expression (Table).68 The interplay between gene and environment in determining the risk of Parkinson disease warrants further study.

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

First Page Preview

View Large
First page PDF preview





Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.


Some tools below are only available to our subscribers or users with an online account.

0 Citations

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.

Articles Related By Topic
Related Collections
PubMed Articles

The Rational Clinical Examination: Evidence-Based Clinical Diagnosis

The Rational Clinical Examination: Evidence-Based Clinical Diagnosis
Make the Diagnosis: Parkinsonism