Accepted for Publication: April 13, 2011.
Author Contributions: Dr T. Siddique had full access to all the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis. Study concept and design: Fecto, Deng, and T. Siddique. Acquisition of data: Fecto, Yan, Vemula, Liu, Yang, Chen, Zheng, Shi, N. Siddique, Arrat, Donkervoort, Ajroud-Driss, Sufit, Heller, Deng, and T. Siddique. Analysis and interpretation of data: Fecto, Deng, and T. Siddique. Drafting of the manuscript: Fecto and T. Siddique. Critical revision of the manuscript for important intellectual content: Yan, Vemula, Liu, Yang, Chen, Zheng, Shi, N. Siddique, Arrat, Donkervoort, Ajroud-Driss, Sufit, Heller, and Deng. Obtained funding: T. Siddique. Study supervision: T. Siddique.
Financial Disclosure: None reported.
Funding/Support: This study was supported by grants NS050641 and T32 AG20506 from the National Institutes of Health and by the Les Turner ALS Foundation, the Vena E. Schaff ALS Research Fund, the Harold Post Research Professorship, the Herbert and Florence C. Wenske Foundation, the Ralph and Marian Falk Medical Research Trust, the David C. Asselin MD Memorial Fund, and the Les Turner ALS Foundation/Herbert C. Wenske Foundation Professorship.
Previous Presentation: This study was presented at the 2011 Annual Meeting of the American Academy of Neurology; April 14, 2011; Honolulu, Hawaii.
Additional Contributions: We thank the patients and families who participated in the study.