Accepted for Publication: March 8, 2011.
Author Contributions:Study concept and design: Saure, Zohren, Schroeder, Kobbe, and Haas. Acquisition of data: Saure, Zohren, Schroeder, Bruns, Cadeddu, Weigelt, Fischer, Hartung, and Adams. Analysis and interpretation of data: Saure, Warnke, Zohren, Schroeder, Cadeddu, Fischer, Kobbe, Adams, Kieseier, and Haas. Drafting of the manuscript: Saure, Warnke, Schroeder, and Fischer. Critical revision of the manuscript for important intellectual content: Warnke, Zohren, Schroeder, Bruns, Cadeddu, Weigelt, Kobbe, Hartung, Adams, Kieseier, and Haas. Statistical analysis: Zohren. Obtained funding: Saure and Schroeder. Administrative, technical, and material support: Saure, Bruns, Cadeddu, Weigelt, Fischer, Kobbe, and Kieseier. Study supervision: Zohren, Weigelt, Kobbe, Hartung, and Haas.
Financial Disclosure: Drs Hartung and Kieseier have received honoraria for lecturing, travel expenses for attending meetings, and financial support for research from Bayer Health Care, Biogen Idec, Merck Serono, Novartis, sanofi-aventis, and TEVA Pharmaceutical Industries Ltd.
Funding/Support: This work was supported by a grant from the Forschungskommission der Medizinischen Fakultät, Düsseldorf, Germany (Dr Saure) and by grant 01GI1002 from the German Ministry for Education and Research (German Competence Network Multiple Sclerosis, Natalizumab-Pharmakovigilanzstudie) (Dr Kieseier).