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Observation |

Whipple Limbic Encephalitis FREE

Frédéric Blanc, MD, PhD; Kaouther Ben Abdelghani, MD; Frédéric Schramm, MD; Benoit Jaulhac, MD, PhD; Emmanuel Chatelus, MD; Christelle Sordet, MD; Jacques-Eric Gottenberg, MD, PhD; Jean Sibilia, MD, PhD
[+] Author Affiliations

Author Affiliations: Neuropsychology Service and CMRR (Memory Resource and Research Centre), Department of Neurology (Dr Blanc), and Departments of Rheumatology (Drs Ben Abdelghani, Chatelus, Sordet, Gottenberg, and Sibilia) and Bacteriology (Drs Schramm and Jaulhac), University Hospital of Strasbourg, and CNRS (Scientific Research National Centre), LINC (Cognitive Neurosciences and Imagery Laboratory), Strasbourg University (Dr Blanc), Strasbourg, France.


Arch Neurol. 2011;68(11):1471-1473. doi:10.1001/archneurol.2011.532.
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Published online

Objective To describe a relapse of Whipple disease revealed by isolated limbic encephalitis with no other signs of systemic involvement.

Design Case report.

Setting University Hospital of Strasbourg, Strasbourg, France.

Patient A 41-year-old patient.

Main Outcome Measures Cognitive functions and results of cerebrospinal fluid analysis and brain magnetic resonance imaging.

Results A 41-year-old patient was hospitalized for headache associated with anterograde amnesia and temporospatial disorientation. Whipple disease with systemic manifestations was diagnosed 4 years previously and insufficiently treated. The neuropsychological evaluation showed impaired episodic memory and executive functions. Analysis of the cerebrospinal fluid showed increased lymphocytes and a positive Tropheryma whipplei polymerase chain reaction result. Cerebral magnetic resonance imaging revealed a typical pattern of limbic encephalitis with an intense signal in the amygdalae and hippocampi. The outcome under antibiotic treatment was marked by partial improvement of the cognitive disorders, disappearance of the positive T whipplei polymerase chain reaction result in cerebrospinal fluid, and a clear decrease of inflammation on brain magnetic resonance imaging.

Conclusions Whipple disease can present as limbic encephalitis. Few cases have been previously described in the literature. Such diagnosis is of importance because of the specific treatment.

Figures in this Article

Whipple disease is a systemic bacterial infection due to Tropheryma whipplei. Its clinical manifestations generally include diarrhea, preceded in most cases by articular symptoms.1 Involvement of the central nervous system is possible, often being polymorphous but rarely isolated.2

Limbic encephalitis (LE) is related to inflammation of the medial temporal lobe. Subacute amnesia is the main clinical symptom and can be associated with seizures and psychiatric symptoms such as depression or personality change. The main etiologies of LE are paraneoplastic,3 autoimmune,4 and viral, particularly herpetic LE. Excluding neurosyphilis,5 very few bacterial infections are responsible for LE.

We report 1 case of a relapse of Whipple disease revealed by isolated LE with no other signs of systemic involvement.

A 41-year-old patient was hospitalized urgently for headache associated with major anterograde amnesia. These symptoms had developed progressively over several months. There was no fever, change in the general state of health, or diarrhea.

The patient was followed up for Whipple disease revealed 4 years earlier by migratory polyarthralgia, episodes of fever, and intermittent diarrhea. The diagnosis had been confirmed by a duodenal biopsy specimen that had shown inflammatory lesions containing macrophages with inclusions positive for periodic acid–Schiff. Results of the T whipplei polymerase chain reaction (PCR) assay on the duodenal biopsy specimen were, however, negative. A course of antibiotics with a third-generation cephalosporin and cotrimoxazole had been prescribed for 15 months, but this treatment had not been maintained by the patient.

On hospital admission, the physical neurological examination was normal without meningeal syndrome. Conversely, a neuropsychological evaluation confirmed the presence of important disorders of the verbal and visual memory. On the Free and Cued Selective Reminding Test6 for verbal episodic memory, the patient had a score of 8 of 16 words for immediate recall (<5th percentile) and scores of 1 of 16 for free recall and 2 of 16 for total recall (<5th percentile). In the visual object recognition memory test (DMS48),7 the patient was deficient, with only 64% correct answers. The Mini-Mental State Examination score was 19 (temporal orientation, 2 of 5; spatial orientation, 2 of 5; attention, 3 of 5; and recall, 0 of 3). There were also disorders of the working memory (backward digit span) and executive functions with an inhibition defect in the go/no go test (error rate of 4 of 40) and defective mental flexibility (error rate of 23 of 40 in the opposing orders test). The Wechsler Adult Intelligence Scale score likewise showed a retardation of the rate of processing of information (<5th percentile). The Rey-Osterrieth complex figure copy was normal.8 The major and predominant effect on the episodic memory was in favor of involvement of the Papez circuit, especially the areas of the medial temporal lobes, while the rest of the cognitive evaluation pointed to involvement of the frontal lobes and, notably, orbitofrontal areas.

The immunological profile (antinuclear antibodies, polynuclear neutrophil anticytoplasmic antibodies, and antiendomysium antibodies) was negative. Immunological tests for intraneuronal antibodies, by immunochemistry and immunoblot including anti-Hu, anti-Yo, anti-Ri, antiamphiphysin, anti-CV2, anti-Ta, and Ma1, were unremarkable. Results of Legionella, cytomegalovirus, Epstein–Barr virus, human immunodeficiency virus, and Lyme disease serologies were likewise negative and levels of vitamins B1, B6, B9, and B12 were normal. Analysis of the cerebrospinal fluid (CSF) revealed 335 leukocytes/mm3 with 99% lymphocytes, and results of T whipplei PCR targeting a 191 base pair–specific fragment of the 16S ribosomal DNA were positive on 2 different aliquots of CSF. The specificity was confirmed by direct sequencing of the amplified DNA fragment showing 100% similarity with T whipplei DNA only. Results of PCR for Herpesviridae (including herpes simplex virus 1, herpes simplex virus 2, varicella-zoster virus, cytomegalovirus, and human herpesvirus 6) were negative. Results of the T whipplei PCR assay were negative on a duodenal biopsy specimen.

Brain magnetic resonance imaging showed diffuse gadolinium enhancement of the leptomeninges and hyperintensity in both the medial temporal lobes and amygdalae on T2 and fluid-attenuated inversion recovery sequences and present to a lesser degree in the insular and frontobasal regions, evoking the diagnosis of meningoencephalitis with limbic involvement (Figure, A).

Place holder to copy figure label and caption
Graphic Jump Location

Figure. Axial T2-weighted fluid-attenuated inversion recovery brain magnetic resonance imaging. A, At the acute phase, showing an intense signal in the amygdalae and hippocampi. B, One year later, showing mild atrophy of the amygdalae and hippocampi.

The electroencephalogram displayed a well-organized cycle of wake and sleep and there was no ictal or interictal pattern. Ophthalmologic examination of the eye revealed the existence of left posterior hyalitis with discrete retinal hemorrhage, possibly evoking the presence of Whipple disease uveitis.

Treatment with a third-generation cephalosporin, trimethoprim-sulfamethoxazole, doxycycline, and hydroxychloroquine was initiated for a period of 2 years. Corticotherapy at a dose of 30 mg/d was administered for 6 weeks.

The evolution was marked by a very clear regression of the cognitive disorders with correct inhibition (no error on the go/no go test), a normal mental flexibility (2 errors on the opposing order test), and normal speed of information processing (normal Wechsler Adult Intelligence Scale score). The Mini-Mental State Examination score was 25 (temporal orientation, 4 of 5; attention, 3 of 5; and recall, 1 of 3). The disturbance of working memory remained unchanged. The episodic memory partially improved, with maximal scores of 11 words of 16 for immediate recall, 1 of 16 for free recall, and 4 of 16 for total recall on the Free and Cued Selective Reminding Test at 3 months and 4 of 16 for free recall and 11 of 16 for total recall at 1 year. On the DMS48 visual recognition test, the patient displayed great improvement and gave 94% and 98% correct answers at 3 months and 1 year, respectively. A new search of T whipplei by PCR in CSF was negative after 1 month of treatment. Follow-up brain magnetic resonance imaging performed after 3 months and 1 year showed a diminution of the internal temporal hypersignal (Figure, B). Conversely, an atrophy of the hippocampus appeared with persistence of a discrete uptake of contrast in the right temporal uncus and at the base of the third ventricle.

This relapse of Whipple disease has the particularity that it was revealed by LE. Involvement of the central nervous system is rare in Whipple disease but represents the most serious complication.9 It occurs during evolution of the disease in 10% to 20% of patients.10 In 2002, Gerard et al2 described in a literature review 122 patients with neuro-Whipple disease. Among these individuals, only 21 displayed isolated initial neurological involvement, while the majority had developed other extraneurological manifestations. Neurological symptoms appear especially in patients whose treatment has not included antibiotics able to cross the blood-brain barrier.11

The neurological manifestations of Whipple disease are extremely diverse and poorly specific. Cognitive impairment is the most frequent and is detected in 71% of patients with neurological involvement.12 These disorders affect memory (25% of cases) and orientation (24% of cases) and can even lead to dementia (28% of cases).2 Oculomasticatory myorrhythmia, always associated with vertical supranuclear gaze palsy, is detected in 8% to 20% of patients and has important diagnostic value as it is encountered only in Whipple disease.2,13

Brain magnetic resonance imaging shows lesions in 53% of cases.12 These lesions consist of T2 or T2-weighted fluid-attenuated inversion recovery hyperintensities, with or without T1 contrast enhancing, located in the medial part of the temporal lobe, hypothalamic region, or pons.14 Forty-two percent of patients also have mild to moderate atrophy.12 In our patient, the lesions were localized in the hippocampi and the amygdalae, typical of LE, with clear inflammation (Figure, A). One year later, there was atrophy of these structures (Figure, B). The involvement of the medial temporal lobe was confirmed by cognitive tests that showed impairment of verbal—without improvement by cueing—and visual memory. To our knowledge, in the literature, no case of Whipple disease was described as a “limbic encephalitis.” But we found 10 cases, including ours, with cognitive impairment and brain magnetic resonance imaging described that correspond to such a syndrome.9,1421 Cases with necropsy have also demonstrated the frequent involvement of the amygdala and the hippocampus (25%).22

Results of CSF PCR analysis have been found to be negative in more than 30% of cases during neurological involvement of Whipple disease.23,24 Conversely, in some patients, results of the PCR assay remain positive in CSF despite antibiotic treatment and sometimes persist for years, without clinical relapse. This positivity can indicate either the persistence of an infectious agent insufficiently controlled by antibiotics or the persistence of residual DNA from dead organisms, which explains the controversial interest of PCR in therapeutic follow-up.13 In our patient, results of the PCR assay became negative after 1 month of antibiotic treatment.

Therapeutic recommendations are not based on any controlled trial. The strategy normally proposed is the administration of 160 mg of trimethoprim and 800 mg of sulfamethoxazole twice daily for 1 to 2 years, but relapse is possible.11 In neurological forms of the disease, a combination of hydroxychloroquine, cyclines, and sulfadiazine has been proposed,25 while according to Cooper et al,26 in the case of neurological relapse while taking trimethoprim-sulfamethoxazole, cefixime can be quite efficacious. Hence, we opted in our case for triple antibiotherapy in association with hydroxychloroquine.

The prognosis in the event of involvement of the central nervous system remains somber, with a mortality of more than 25% at 4 years. One-quarter of the patients have severe sequelae.27 The evolution of our patient's disease was marked by partial persistence of the amnesia.

Correspondence: Jean Sibilia, MD, PhD, Service de Rhumatologie, Centre national de référence des maladies auto-immunes systémiques rares, Hôpital de Hautepierre, CHU de Strasbourg, 1 Ave Molière, 67098 Strasbourg CEDEX, France (jean.sibilia@wanadoo.fr).

Accepted for Publication: April 20, 2011.

Author Contributions: Drs Blanc and Ben Abdelghani equally contributed to this study. Study concept and design: Blanc and Sibilia. Acquisition of data: Blanc, Ben Abdelghani, Chatelus, Sordet, Gottenberg, and Sibilia. Analysis and interpretation of data: Blanc, Schramm, Jaulhac, Gottenberg, and Sibilia. Drafting of the manuscript: Blanc, Ben Abdelghani, Schramm, Jaulhac, and Sibilia. Critical revision of the manuscript for important intellectual content: Blanc, Chatelus, Sordet, and Gottenberg. Administrative, technical, and material support: Chatelus and Sordet. Study supervision: Blanc and Sibilia.

Financial Disclosure: None reported.

Fenollar F, Puéchal X, Raoult D. Whipple's disease.  N Engl J Med. 2007;356(1):55-66
PubMed   |  Link to Article
Gerard A, Sarrot-Reynauld F, Liozon E,  et al.  Neurologic presentation of Whipple disease: report of 12 cases and review of the literature.  Medicine (Baltimore). 2002;81(6):443-457
PubMed   |  Link to Article
Gultekin SH, Rosenfeld MR, Voltz R, Eichen J, Posner JB, Dalmau J. Paraneoplastic limbic encephalitis: neurological symptoms, immunological findings and tumour association in 50 patients.  Brain. 2000;123(pt 7):1481-1494
PubMed   |  Link to Article
Blanc F, Ruppert E, Kleitz C,  et al.  Acute limbic encephalitis and glutamic acid decarboxylase antibodies: a reality?  J Neurol Sci. 2009;287(1-2):69-71
PubMed   |  Link to Article
Scheid R, Voltz R, Vetter T, Sabri O, von Cramon DY. Neurosyphilis and paraneoplastic limbic encephalitis: important differential diagnoses.  J Neurol. 2005;252(9):1129-1132
PubMed   |  Link to Article
Grober E, Buschke H. Genuine memory deficits in dementia.  Dev Neuropsychol. 1987;3(1):13-36Link to Article
Link to Article
Barbeau E, Didic M, Tramoni E,  et al.  Evaluation of visual recognition memory in MCI patients.  Neurology. 2004;62(8):1317-1322
PubMed   |  Link to Article
Rey A. The psychological examination in cases of traumatic encephalopathy.  Arch Psychol. 1941;28:215-285
Frazier JL, Quinones-Hinojosa A. Isolated Whipple disease of the brain resembling a tumour.  Acta Neurochir (Wien). 2009;151(2):173-175
PubMed   |  Link to Article
Puéchal X. Whipple's disease.  Joint Bone Spine. 2002;69(2):133-140
PubMed   |  Link to Article
Benito-León J, Sedano LF, Louis ED. Isolated central nervous system Whipple's disease causing reversible frontotemporal-like dementia.  Clin Neurol Neurosurg. 2008;110(7):747-749
PubMed   |  Link to Article
Louis ED, Lynch T, Kaufmann P, Fahn S, Odel J. Diagnostic guidelines in central nervous system Whipple's disease.  Ann Neurol. 1996;40(4):561-568
PubMed   |  Link to Article
Puéchal X. Whipple's disease [in French].  Rev Med Interne. 2009;30(3):233-241
PubMed   |  Link to Article
Kremer S, Besson G, Bonaz B, Pasquier B, Le Bas JF, Grand S. Diffuse lesions in the CNS revealed by MR imaging in a case of Whipple disease.  AJNR Am J Neuroradiol. 2001;22(3):493-495
PubMed
Panegyres PK, Foster JK, Fallon M, Connor C. The amnesic syndrome of primary Whipple disease of the brain.  Cogn Behav Neurol. 2010;23(1):49-51
PubMed   |  Link to Article
Manzel K, Tranel D, Cooper G. Cognitive and behavioral abnormalities in a case of central nervous system Whipple disease.  Arch Neurol. 2000;57(3):399-403
PubMed   |  Link to Article
Leesch W, Fischer I, Staudinger R, Miller DC, Sathe S. Primary cerebral Whipple disease presenting as Klüver-Bucy syndrome.  Arch Neurol. 2009;66(1):130-131
PubMed   |  Link to Article
Schnider P, Trattnig S, Kollegger H, Auff E. MR of cerebral Whipple disease.  AJNR Am J Neuroradiol. 1995;16(6):1328-1329
PubMed
El Helou J, Saliba G, Kolev I, Pierrot-Deseilligny C. Neuro-Whipple confirmed five years after a presumptive diagnosis of a primitive CNS vasculitis.  J Neurol. 2008;255(6):925-926
PubMed   |  Link to Article
Raheja AA, Lui YW, Pinzon-Ardila A, Lim RP, Sparr SA. Use of diffusion-weighted imaging in recurrent central nervous system Whipple's disease: a case report and review of the literature.  Clin Imaging. 2010;34(2):143-147
PubMed   |  Link to Article
Bültmann E, Ernemann U, Nägele T. Unusual cerebral manifestation of Whipple disease [in German].  Rofo. 2005;177(8):1164-1166
PubMed   |  Link to Article
Stoupel N, Monseu G, Pardoe A, Heimann R, Martin JJ. Encephalitis with myoclonus in Whipple's disease.  J Neurol Neurosurg Psychiatry. 1969;32(4):338-343
PubMed   |  Link to Article
Lo Monaco A, Govoni M, Zelante A,  et al.  Whipple disease: unusual presentation of a protean and sometimes confusing disease.  Semin Arthritis Rheum. 2009;38(5):403-406
PubMed   |  Link to Article
von Herbay A, Ditton HJ, Schuhmacher F, Maiwald M. Whipple's disease: staging and monitoring by cytology and polymerase chain reaction analysis of cerebrospinal fluid.  Gastroenterology. 1997;113(2):434-441
PubMed   |  Link to Article
Schneider T, Moos V, Loddenkemper C, Marth T, Fenollar F, Raoult D. Whipple's disease: new aspects of pathogenesis and treatment.  Lancet Infect Dis. 2008;8(3):179-190
PubMed   |  Link to Article
Cooper GS, Blades EW, Remler BF, Salata RA, Bennert KW, Jacobs GH. Central nervous system Whipple's disease: relapse during therapy with trimethoprim-sulfamethoxazole and remission with cefixime.  Gastroenterology. 1994;106(3):782-786
PubMed
Schnider PJ, Reisinger EC, Gerschlager W,  et al.  Long-term follow-up in cerebral Whipple's disease.  Eur J Gastroenterol Hepatol. 1996;8(9):899-903
PubMed

Figures

Place holder to copy figure label and caption
Graphic Jump Location

Figure. Axial T2-weighted fluid-attenuated inversion recovery brain magnetic resonance imaging. A, At the acute phase, showing an intense signal in the amygdalae and hippocampi. B, One year later, showing mild atrophy of the amygdalae and hippocampi.

Tables

References

Fenollar F, Puéchal X, Raoult D. Whipple's disease.  N Engl J Med. 2007;356(1):55-66
PubMed   |  Link to Article
Gerard A, Sarrot-Reynauld F, Liozon E,  et al.  Neurologic presentation of Whipple disease: report of 12 cases and review of the literature.  Medicine (Baltimore). 2002;81(6):443-457
PubMed   |  Link to Article
Gultekin SH, Rosenfeld MR, Voltz R, Eichen J, Posner JB, Dalmau J. Paraneoplastic limbic encephalitis: neurological symptoms, immunological findings and tumour association in 50 patients.  Brain. 2000;123(pt 7):1481-1494
PubMed   |  Link to Article
Blanc F, Ruppert E, Kleitz C,  et al.  Acute limbic encephalitis and glutamic acid decarboxylase antibodies: a reality?  J Neurol Sci. 2009;287(1-2):69-71
PubMed   |  Link to Article
Scheid R, Voltz R, Vetter T, Sabri O, von Cramon DY. Neurosyphilis and paraneoplastic limbic encephalitis: important differential diagnoses.  J Neurol. 2005;252(9):1129-1132
PubMed   |  Link to Article
Grober E, Buschke H. Genuine memory deficits in dementia.  Dev Neuropsychol. 1987;3(1):13-36Link to Article
Link to Article
Barbeau E, Didic M, Tramoni E,  et al.  Evaluation of visual recognition memory in MCI patients.  Neurology. 2004;62(8):1317-1322
PubMed   |  Link to Article
Rey A. The psychological examination in cases of traumatic encephalopathy.  Arch Psychol. 1941;28:215-285
Frazier JL, Quinones-Hinojosa A. Isolated Whipple disease of the brain resembling a tumour.  Acta Neurochir (Wien). 2009;151(2):173-175
PubMed   |  Link to Article
Puéchal X. Whipple's disease.  Joint Bone Spine. 2002;69(2):133-140
PubMed   |  Link to Article
Benito-León J, Sedano LF, Louis ED. Isolated central nervous system Whipple's disease causing reversible frontotemporal-like dementia.  Clin Neurol Neurosurg. 2008;110(7):747-749
PubMed   |  Link to Article
Louis ED, Lynch T, Kaufmann P, Fahn S, Odel J. Diagnostic guidelines in central nervous system Whipple's disease.  Ann Neurol. 1996;40(4):561-568
PubMed   |  Link to Article
Puéchal X. Whipple's disease [in French].  Rev Med Interne. 2009;30(3):233-241
PubMed   |  Link to Article
Kremer S, Besson G, Bonaz B, Pasquier B, Le Bas JF, Grand S. Diffuse lesions in the CNS revealed by MR imaging in a case of Whipple disease.  AJNR Am J Neuroradiol. 2001;22(3):493-495
PubMed
Panegyres PK, Foster JK, Fallon M, Connor C. The amnesic syndrome of primary Whipple disease of the brain.  Cogn Behav Neurol. 2010;23(1):49-51
PubMed   |  Link to Article
Manzel K, Tranel D, Cooper G. Cognitive and behavioral abnormalities in a case of central nervous system Whipple disease.  Arch Neurol. 2000;57(3):399-403
PubMed   |  Link to Article
Leesch W, Fischer I, Staudinger R, Miller DC, Sathe S. Primary cerebral Whipple disease presenting as Klüver-Bucy syndrome.  Arch Neurol. 2009;66(1):130-131
PubMed   |  Link to Article
Schnider P, Trattnig S, Kollegger H, Auff E. MR of cerebral Whipple disease.  AJNR Am J Neuroradiol. 1995;16(6):1328-1329
PubMed
El Helou J, Saliba G, Kolev I, Pierrot-Deseilligny C. Neuro-Whipple confirmed five years after a presumptive diagnosis of a primitive CNS vasculitis.  J Neurol. 2008;255(6):925-926
PubMed   |  Link to Article
Raheja AA, Lui YW, Pinzon-Ardila A, Lim RP, Sparr SA. Use of diffusion-weighted imaging in recurrent central nervous system Whipple's disease: a case report and review of the literature.  Clin Imaging. 2010;34(2):143-147
PubMed   |  Link to Article
Bültmann E, Ernemann U, Nägele T. Unusual cerebral manifestation of Whipple disease [in German].  Rofo. 2005;177(8):1164-1166
PubMed   |  Link to Article
Stoupel N, Monseu G, Pardoe A, Heimann R, Martin JJ. Encephalitis with myoclonus in Whipple's disease.  J Neurol Neurosurg Psychiatry. 1969;32(4):338-343
PubMed   |  Link to Article
Lo Monaco A, Govoni M, Zelante A,  et al.  Whipple disease: unusual presentation of a protean and sometimes confusing disease.  Semin Arthritis Rheum. 2009;38(5):403-406
PubMed   |  Link to Article
von Herbay A, Ditton HJ, Schuhmacher F, Maiwald M. Whipple's disease: staging and monitoring by cytology and polymerase chain reaction analysis of cerebrospinal fluid.  Gastroenterology. 1997;113(2):434-441
PubMed   |  Link to Article
Schneider T, Moos V, Loddenkemper C, Marth T, Fenollar F, Raoult D. Whipple's disease: new aspects of pathogenesis and treatment.  Lancet Infect Dis. 2008;8(3):179-190
PubMed   |  Link to Article
Cooper GS, Blades EW, Remler BF, Salata RA, Bennert KW, Jacobs GH. Central nervous system Whipple's disease: relapse during therapy with trimethoprim-sulfamethoxazole and remission with cefixime.  Gastroenterology. 1994;106(3):782-786
PubMed
Schnider PJ, Reisinger EC, Gerschlager W,  et al.  Long-term follow-up in cerebral Whipple's disease.  Eur J Gastroenterol Hepatol. 1996;8(9):899-903
PubMed

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Encephalitis with myoclonus in Whipple's disease. J Neurol Neurosurg Psychiatry 1969;32(4):338-43.
Whipple limbic encephalitis. Arch Neurol 2011;68(11):1471-3.