Accepted for Publication: April 6, 2011.
Author Contributions: Dr Selkoe had full access to all the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis. Study concept and design: Shankar and Selkoe. Acquisition of data: Shepardson and Shankar. Analysis and interpretation of data: Shepardson, Shankar, and Selkoe. Drafting of the manuscript: Shepardson and Shankar. Critical revision of the manuscript for important intellectual content: Shepardson and Selkoe. Statistical analysis: Shankar. Obtained funding: Selkoe. Administrative, technical, and material support: Selkoe. Study supervision: Shankar and Selkoe.
Financial Disclosure: Dr Selkoe is a founding scientist and consultant of Elan PLC.
Funding/Support: This study was supported by grant AG06173 from the National Institutes of Health (Dr Selkoe).
Role of the Sponsor: The funding organization had no role in the design and conduct of the study; in the collection, analysis, and interpretation of the data; or in the preparation, review, or approval of the manuscript.
Additional Contributions: Francine Grodstein, ScD, of the Harvard School of Public Health and Benjamin Wolozin, MD, PhD, of the Boston University School of Medicine provided insightful comments and suggestions on an earlier draft of this article and did not receive financial compensation for their contributions.