Accepted for Publication: February 17, 2011.
Author Contributions:Study concept and design: Klein and Dyck. Acquisition of data: Klein, Engelstad, and Cunningham. Analysis and interpretation of data: Klein, Kimmel, Pittock, and Wu. Drafting of the manuscript: Klein and Kimmel. Critical revision of the manuscript for important intellectual content: Klein, Pittock, Engelstad, Cunningham, Wu, and Dyck. Statistical analysis: Klein. Obtained funding: Klein. Administrative, technical, and material support: Klein and Kimmel. Study supervision: Klein and Dyck.
Financial Disclosure: Dr Pittock and Mayo Clinic have a financial interest in the technology titled “Aquaporin-4 Autoantibody as a Cancer Marker,” which has been licensed to a commercial entity, but no royalties have been received. In addition, he is an inventor of technology titled “Aquaporin-4 Binding Autoantibodies in Patients With Neuromyelitis Optic Impair Glutamate Transport by Down-Regulating EAAT2.” Mayo Clinic has filed a nonprovisional patent application for this technology. Also, he received a research grant from Alexion Pharmaceuticals for his investigator-initiated study titled “An Open Label Study of Eculizumab in NMO.” Dr Pittock is a consultant in the Department of Laboratory Medicine and Pathology. In his role as codirector of the Neuroimmunology Laboratory, he has no additional intellectual property related to any tests performed on a service basis in the laboratory. He receives no royalties from the sale of these tests when used for patients. Mayo Collaborative Services, Inc, does receive revenue for conducting these tests.
Funding/Support: This work was funded by grant K08 NS065007 from the National Institutes of Health and a Mayo Foundation Neuroscience Development award (Dr Klein).
Additional Contributions: We thank the family for their participation and Mr Larry Witt for coordinating the DNA library used in this work.