Accepted for Publication: March 15, 2011.
Author Contributions: Dr Xiong had full access to all the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis. Study concept and design: Xiong, Roe, Buckles, Mintun, Csernansky, and Morris. Acquisition of data: Fagan, Balota, Duchek, Storandt, Mintun, Grant, Head, Benzinger, Mettenburg, and Morris. Analysis and interpretation of data: Xiong, Roe, Buckles, Holtzman, Duchek, Snyder, Benzinger, and Morris. Drafting of the manuscript: Xiong, Balota, and Snyder. Critical revision of the manuscript for important intellectual content: Xiong, Roe, Buckles, Fagan, Holtzman, Duchek, Storandt, Mintun, Grant, Head, Benzinger, Mettenburg, Csernansky, and Morris. Statistical analysis: Xiong, Roe, and Duchek. Obtained funding: Xiong, Balota, Storandt, Head, and Morris. Administrative, technical, and material support: Buckles, Fagan, Holtzman, Duchek, Mintun, Grant, Snyder, Csernansky, and Morris. Study supervision: Storandt, Mintun, Benzinger, and Morris.
Financial Disclosure: Dr Holtzman reports that he receives research funding from Eli Lilly and Company, AstraZeneca, Pfizer, and C2N Diagnostics through Washington University; he is a member of the scientific advisory board for En Vivo, Satori, and C2N Diagnostics; and he is a consultant for Innogenetics. Dr Mintun reports that he is the chief medical officer for Avid Radiopharmaceuticals.
Funding/Support: This study was supported by grant P01 AG026276 from the National Institute on Aging (Dr Morris), the American Roentgen Ray Scholar Award (Dr Benzinger), and grant P50 AG05681 from the Charles F. and Joanne Knight Alzheimer's Research Initiative of the Washington University Alzheimer's Disease Research Center (Dr Morris).
Additional Contributions: We thank the Genetics Core (Alison Goate, DPhil, Core Leader) of the Alzheimer's Disease Research Center for the APOE data.