Accepted for Publication: April 1, 2011.
Author Contributions: Dr Selkoe had full access to all the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis. Study concept and design: Shankar. Acquisition of data: Shepardson and Shankar. Analysis and interpretation of data: Shepardson and Selkoe. Drafting of the manuscript: Shepardson and Shankar. Critical revision of the manuscript for important intellectual content: Selkoe, Shepardson, and Shankar. Obtained funding: Selkoe. Study supervision: Selkoe.
Financial Disclosure: Dr Selkoe is a founding scientist and consultant of Elan Corporation, PLC.
Funding/Support: This study was supported by grant AG06173 from the National Institutes of Health (Dr Selkoe).
Disclaimer: The funding organization had no role in design or conduct of the study; collection, management, analysis, or interpretation of the data; or preparation, review, or approval of the manuscript.
Additional Contributions: Francine Grodstein, ScD, and Benjamin Wolozin, MD, PhD, provided insightful comments and suggestions on an early draft of the manuscript.