0
From JAMA |

Failure to Take Antiepileptic Drugs as Prescribed:  A Socioeconomic Issue After All

Pradeep N. Modur, MD, MS
Arch Neurol. 2011;68(10):1320-1322. doi:10.1001/archneurol.2011.224.
Text Size: A A A
Published online

Extract

Epilepsy is a chronic illness that affects 1% of the population. It is characterized by the occurrence of recurrent, unprovoked seizures. At present, therapy with antiepileptic drugs (AEDs) remains the cornerstone of treatment for epilepsy. The currently available AEDs are anticonvulsant rather than antiepileptogenic in nature, in that they control the seizures symptomatically without modifying the underlying disease process. Because the seizures are largely unpredictable in timing and severity, adequate treatment of epilepsy entails regular administration of AEDs for an indefinite period of time. Such a treatment strategy, simply by virtue of its nature, is fraught with problems of nonadherence to the prescribed regimen. Many patients are dismayed by the fact that there are no reliable or readily identifiable markers to indicate that strict adherence to the prescribed regimen will indeed prevent future seizures. Thus, it is not surprising to encounter nonadherence among patients with epilepsy, whether suspected by the clinicians or reported by the patients themselves. Recent studies have shown the rate of nonadherence to AEDs in adult patients to be in the range of 26% to 41%.1,2 Although occasional unintentional nonadherence to AEDs (eg, forgetting to take the medication once in a while) is acceptable, the consequences of chronic nonadherence (intentional or unintentional) are not necessarily trivial. As documented in the literature, nonadherence to AEDs is associated with significantly increased risk of seizures, morbidity (eg, injuries), mortality, emergency department visits, and hospital admissions, all of which can contribute to a higher overall cost of health care.13

Topics

Sign In to Access Full Content

Don't have Access?

Register and get free email Table of Contents alerts, saved searches, PowerPoint downloads, CME quizzes, and more

Subscribe for full-text access to content from 1998 forward and a host of useful features

Activate your current subscription (AMA members and current subscribers)

Purchase Online Access to this article for 24 hours

Figures

Tables

References

Correspondence

CME
Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).
Submit a Comment

Multimedia

Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

Related Content

Customize your page view by dragging & repositioning the boxes below.

Jobs
brightcove.createExperiences();